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Fungal genomics is a scientific discipline that concerns the genome, encompassing the entire hereditary information, of fungi. Fungal genomics can, for example, be used to study fungal evolution or outbreaks of fungal infections.
Comparative genomics of 24 Penicillium species, including 9 that are newly sequenced, characterizes over 1000 secondary metabolism gene clusters, some of which are validated experimentally, identifying these fungi as an important untapped source of bioactive compounds.
The fungal Ascomycota provide a model phylum to investigate the evolution of complex multicellularity. Here, the authors combine genome sequencing with comparative and functional genomics to identify diverse endomembrane related machineries associated with the gain and loss of fungal complexity.