Epistasis articles within Nature

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• Article
  10 January 2024 | Open Access

  A lethal mitonuclear incompatibility in complex I of natural hybrids

  Analysis of naturally hybridizing swordtail fish species reveals a mitonuclear genetic incompatibility among three genes that encode components of mitochondrial respiratory complex I, providing insights into the emergence of hybrid incompatibilities and reproductive barriers.

  • Benjamin M. Moran
  • , Cheyenne Y. Payne
  •  & Molly Schumer

• Matters Arising | 11 August 2021

  Phantom epistasis between unlinked loci

  • Gibran Hemani
  • , Joseph E. Powell
  •  & Peter M. Visscher

• Article | 23 September 2020

  Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

  Genome-wide CRISPR screens in mouse cancer cell lines are used to identify a core, conserved set of genes and pathways that govern how cancer cells evade killing by cytotoxic T lymphocytes.

  • Keith A. Lawson
  • , Cristovão M. Sousa
  •  & Jason Moffat

• Letter | 30 May 2018

  Pairwise and higher-order genetic interactions during the evolution of a tRNA

  Mutagenesis of a yeast tRNA shows that the effects of mutations and how they interact varies both in magnitude and sign between genotypes.

  • Júlia Domingo
  • , Guillaume Diss
  •  & Ben Lehner

• Article | 16 May 2018

  ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase

  ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.

  • My-Nuong Vo
  • , Markus Terrey
  •  & Susan L. Ackerman

• Letter | 31 May 2017

  Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

  Random mutagenesis in haploid human cells coupled to quantitative protein measurements with different antibodies is used as a readout for individual cellular phenotypes.

  • Markus Brockmann
  • , Vincent A. Blomen
  •  & Thijn R. Brummelkamp

• Letter | 29 June 2015

  Identification of cis-suppression of human disease mutations by comparative genomics

  Patterns of amino acid conservation have been used to guide the interpretation of the disease-causing potential of genetic variants in patients; now, an appreciable fraction of pathogenic alleles are shown to be fixed in the genomes of other species, suggesting that the genomic context has an important role in allele pathogenicity.

  • Daniel M. Jordan
  • , Stephan G. Frangakis
  •  & Nicholas Katsanis