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“LSD1 is a histone demethylase that plays many roles during development. Here, the authors provide evidence that loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex and suggest a potential link between LSD1 and human neurodegenerative disease.
Neurons require lifelong maintenance of their transcriptional program, which includes stable expression of cell-type-specific identity genes. A study now shows that PRC2-mediated chromatin repression in adulthood is critical for the maintenance of neuronal identity gene expression and neuronal survival.
Endocrine disruptors are critical environmental exposures that influence health
and can promote epigenetic transgenerational inheritance of disease and abnormal
physiology. Advances in 2015 included analyses of the effects of endocrine disruptors on
human disease, further examples of endocrine disruptors promoting transgenerational
behavioural effects, insights into effects of endocrine disruptors on epigenetic
programming of primordial germ cells and the finding that endocrine disruptors can
transgenerationally promote genetic mutations.
A leading therapeutic molecule for multiple sclerosis, FTY720, is shown to mimic a key component of sphingolipid signaling, resulting in specific manipulation of histone deacetylases and the extinction of memory.