Embryonal neoplasms

Embryonal neoplasms are tumours formed from a mass of rapidly growing cells that begin in embryonic (fetal) tissue and express one or more embryo-exclusive genes. They account for 2–3 % of germ cell tumours. They can be benign or malignant. The disease type does not include neoplasms located in an embryo or foetus.

Latest Research and Reviews

  • Research | | open

    In gene regulation, diversification at the transcriptome 3′end is linked to differentiation and dedifferentiation. Here, the authors discover extensive transcriptome 3′end-alterations in neuroblastoma, regulated by PCF11, and provide an interactive data repository of transcriptome-wide alternative polyadenylation.

    • Anton Ogorodnikov
    • , Michal Levin
    • , Surendra Tattikota
    • , Sergey Tokalov
    • , Mainul Hoque
    • , Denise Scherzinger
    • , Federico Marini
    • , Ansgar Poetsch
    • , Harald Binder
    • , Stephan Macher-Göppinger
    • , Hans Christian Probst
    • , Bin Tian
    • , Michael Schaefer
    • , Karl J. Lackner
    • , Frank Westermann
    •  & Sven Danckwardt
  • Research |

    Elizabeth Perlman and colleagues use genome-wide sequencing, RNA expression, DNA copy number and methylation analyses to characterize the genomic landscape of Wilms tumors. Their integrated analyses implicate two major classes of genetic changes in Wilms tumors that preserve the progenitor state and/or interrupt normal kidney development.

    • Samantha Gadd
    • , Vicki Huff
    • , Amy L Walz
    • , Ariadne H A G Ooms
    • , Amy E Armstrong
    • , Daniela S Gerhard
    • , Malcolm A Smith
    • , Jaime M Guidry Auvil
    • , Daoud Meerzaman
    • , Qing-Rong Chen
    • , Chih Hao Hsu
    • , Chunhua Yan
    • , Cu Nguyen
    • , Ying Hu
    • , Leandro C Hermida
    • , Tanja Davidsen
    • , Patee Gesuwan
    • , Yussanne Ma
    • , Zusheng Zong
    • , Andrew J Mungall
    • , Richard A Moore
    • , Marco A Marra
    • , Jeffrey S Dome
    • , Charles G Mullighan
    • , Jing Ma
    • , David A Wheeler
    • , Oliver A Hampton
    • , Nicole Ross
    • , Julie M Gastier-Foster
    • , Stefan T Arold
    •  & Elizabeth J Perlman
    Nature Genetics 49, 1487-1494
  • Research |

    Isabelle Janoueix-Lerosey, Valentina Boeva and colleagues analyze the super-enhancer landscape of 25 neuroblastoma cell lines to define core regulatory circuits controlling gene expression programs. They find and functionally characterize two types of cell identity that contribute to the tumor heterogeneity of neuroblastoma.

    • Valentina Boeva
    • , Caroline Louis-Brennetot
    • , Agathe Peltier
    • , Simon Durand
    • , Cécile Pierre-Eugène
    • , Virginie Raynal
    • , Heather C Etchevers
    • , Sophie Thomas
    • , Alban Lermine
    • , Estelle Daudigeos-Dubus
    • , Birgit Geoerger
    • , Martin F Orth
    • , Thomas G P Grünewald
    • , Elise Diaz
    • , Bertrand Ducos
    • , Didier Surdez
    • , Angel M Carcaboso
    • , Irina Medvedeva
    • , Thomas Deller
    • , Valérie Combaret
    • , Eve Lapouble
    • , Gaelle Pierron
    • , Sandrine Grossetête-Lalami
    • , Sylvain Baulande
    • , Gudrun Schleiermacher
    • , Emmanuel Barillot
    • , Hermann Rohrer
    • , Olivier Delattre
    •  & Isabelle Janoueix-Lerosey
    Nature Genetics 49, 1408-1413

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