Embryonal neoplasms

Definition

Embryonal neoplasms are tumours formed from a mass of rapidly growing cells that begin in embryonic (fetal) tissue and express one or more embryo-exclusive genes. They account for 2–3 % of germ cell tumours. They can be benign or malignant. The disease type does not include neoplasms located in an embryo or foetus.

Latest Research and Reviews

  • Research |

    Elizabeth Perlman and colleagues use genome-wide sequencing, RNA expression, DNA copy number and methylation analyses to characterize the genomic landscape of Wilms tumors. Their integrated analyses implicate two major classes of genetic changes in Wilms tumors that preserve the progenitor state and/or interrupt normal kidney development.

    • Samantha Gadd
    • , Vicki Huff
    • , Amy L Walz
    • , Ariadne H A G Ooms
    • , Amy E Armstrong
    • , Daniela S Gerhard
    • , Malcolm A Smith
    • , Jaime M Guidry Auvil
    • , Daoud Meerzaman
    • , Qing-Rong Chen
    • , Chih Hao Hsu
    • , Chunhua Yan
    • , Cu Nguyen
    • , Ying Hu
    • , Leandro C Hermida
    • , Tanja Davidsen
    • , Patee Gesuwan
    • , Yussanne Ma
    • , Zusheng Zong
    • , Andrew J Mungall
    • , Richard A Moore
    • , Marco A Marra
    • , Jeffrey S Dome
    • , Charles G Mullighan
    • , Jing Ma
    • , David A Wheeler
    • , Oliver A Hampton
    • , Nicole Ross
    • , Julie M Gastier-Foster
    • , Stefan T Arold
    •  & Elizabeth J Perlman
    Nature Genetics 49, 1487–1494
  • Research |

    Isabelle Janoueix-Lerosey, Valentina Boeva and colleagues analyze the super-enhancer landscape of 25 neuroblastoma cell lines to define core regulatory circuits controlling gene expression programs. They find and functionally characterize two types of cell identity that contribute to the tumor heterogeneity of neuroblastoma.

    • Valentina Boeva
    • , Caroline Louis-Brennetot
    • , Agathe Peltier
    • , Simon Durand
    • , Cécile Pierre-Eugène
    • , Virginie Raynal
    • , Heather C Etchevers
    • , Sophie Thomas
    • , Alban Lermine
    • , Estelle Daudigeos-Dubus
    • , Birgit Geoerger
    • , Martin F Orth
    • , Thomas G P Grünewald
    • , Elise Diaz
    • , Bertrand Ducos
    • , Didier Surdez
    • , Angel M Carcaboso
    • , Irina Medvedeva
    • , Thomas Deller
    • , Valérie Combaret
    • , Eve Lapouble
    • , Gaelle Pierron
    • , Sandrine Grossetête-Lalami
    • , Sylvain Baulande
    • , Gudrun Schleiermacher
    • , Emmanuel Barillot
    • , Hermann Rohrer
    • , Olivier Delattre
    •  & Isabelle Janoueix-Lerosey
    Nature Genetics 49, 1408–1413
  • Research |

    Alex Kentsis and colleagues identify somatic genomic rearrangements in primary human rhabdoid tumors characterized by deletions and inversions involving PGBD5-specific signal sequences at their breakpoints. They further show that ectopic expression of PGBD5 in primary immortalized human cells is sufficient to promote cell transformation in vitro and in immunodeficient mice in vivo, thus defining PGBD5 as an oncogenic mutator and providing a plausible mechanism for site-specific DNA rearrangements in solid tumors.

    • Anton G Henssen
    • , Richard Koche
    • , Jiali Zhuang
    • , Eileen Jiang
    • , Casie Reed
    • , Amy Eisenberg
    • , Eric Still
    • , Ian C MacArthur
    • , Elias Rodríguez-Fos
    • , Santiago Gonzalez
    • , Montserrat Puiggròs
    • , Andrew N Blackford
    • , Christopher E Mason
    • , Elisa de Stanchina
    • , Mithat Gönen
    • , Anne-Katrin Emde
    • , Minita Shah
    • , Kanika Arora
    • , Catherine Reeves
    • , Nicholas D Socci
    • , Elizabeth Perlman
    • , Cristina R Antonescu
    • , Charles W M Roberts
    • , Hanno Steen
    • , Elizabeth Mullen
    • , Stephen P Jackson
    • , David Torrents
    • , Zhiping Weng
    • , Scott A Armstrong
    •  & Alex Kentsis
    Nature Genetics 49, 1005–1014

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