Dystonia articles within Nature Communications

Featured

• Article
  14 December 2023 | Open Access

  Automating General Movements Assessment with quantitative deep learning to facilitate early screening of cerebral palsy

  General Movements Assessment (GMA) is useful in early prediction of cerebral palsy but necessitates trained professionals. Here, the authors show a quantitative deep learning-based method to automate GMA with strong performance, adhering to GMA principles and exhibiting robust interpretability.

  • Qiang Gao
  • , Siqiong Yao
  •  & Hui Lu

• Article
  04 April 2017 | Open Access

  Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice

  Dystonia is thought to be driven by impairments in cerebellar signalling. The authors use a mouse genetic approach to silence excitatory transmission in the inferior olive to cerebellum pathway, resulting in dystonia-like signs in the animals which can be alleviated using DBS stimulation of the pathway.

  • Joshua J. White
  •  & Roy V. Sillitoe

• Article
  27 May 2016 | Open Access

  Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia

  Karin Tuschl, Philippa Mills and colleagues report mutations in the manganese (Mn) transporter gene SLC39A14in childhood-onset parkinsonism-dystonia. Using functional recapitulation, the authors also show that slc39A14 loss-of-function in zebrafish can lead to Mn dysregulation and locomotor impairment.

  • Karin Tuschl
  • , Esther Meyer
  •  & Stephen W. Wilson