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Diarrhoea describes loose or liquid stools passed at a rate more frequent than is usual for the patient. Gastroenteritis is the most common cause of diarrhoea. Chronic diarrhoea is a symptom of several conditions, including ulcerative colitis and coeliac disease.
Gastrointestinal dysfunction is very common in patients with systemic sclerosis, and often severely reduces quality of life. In this Review, Emmanuel discusses optimal strategies to identify and manage gastrointestinal complications in patients with systemic sclerosis, and outlines potential new therapies.
The intestinal brush border consists of an array of densely packed microvilli that regulate absorption of nutrients. In this Review, the authors provide an overview of the many components that form the highly organized brush border domain and discuss pathological causes and consequences of a loss of brush border integrity.
Secretory diarrhoeas are a major cause of mortality and morbidity globally,
especially in vulnerable populations such as children and the elderly. Diarrhoea has
many environmental causes such as infection with bacteria or viruses, but it can also be
a result of genetic defects. In this Review the authors describe the pathogenic
mechanisms of secretory diarrhoea and discuss the available therapies and experimental
therapies that are being developed.