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Diarrhoea describes loose or liquid stools passed at a rate more frequent than is usual for the patient. Gastroenteritis is the most common cause of diarrhoea. Chronic diarrhoea is a symptom of several conditions, including ulcerative colitis and coeliac disease.
Gastrointestinal dysfunction is very common in patients with systemic sclerosis, and often severely reduces quality of life. In this Review, Emmanuel discusses optimal strategies to identify and manage gastrointestinal complications in patients with systemic sclerosis, and outlines potential new therapies.
The intestinal brush border consists of an array of densely packed microvilli that regulate absorption of nutrients. In this Review, the authors provide an overview of the many components that form the highly organized brush border domain and discuss pathological causes and consequences of a loss of brush border integrity.