Featured
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Letter |
Altered human oligodendrocyte heterogeneity in multiple sclerosis
Single-nucleus RNA sequencing analysis identifies different subclusters of oligodendroglia in white matter from individuals with multiple sclerosis compared with controls, and these differences may be important for understanding disease progression.
- Sarah Jäkel
- , Eneritz Agirre
- & Gonçalo Castelo-Branco
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Outlook |
Diagnostics: Getting a clear picture
Technologies that better reveal the insidious progression of multiple sclerosis could aid the search for treatments.
- Cynthia Graber
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Letter |
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
- Kerstin Berer
- , Marsilius Mues
- & Gurumoorthy Krishnamoorthy
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Letter
| Open Access
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis
Studies of identical twins are widely used to dissect the contributions of genes and the environment to human diseases. In multiple sclerosis, an autoimmune demyelinating disease, identical twins often show differences. This might suggest that environmental effects are most significant in this case, but genetic and epigenetic differences between identical twins have been described. Here, however, studies of identical twins show no evidence for genetic, epigenetic or transcriptome differences that could explain disease discordance.
- Sergio E. Baranzini
- , Joann Mudge
- & Stephen F. Kingsmore
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Research Highlights |
Neurobiology: Prions at work
A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis