Consanguinity articles within Nature Communications

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  • Article
    | Open Access

    Little is known about the recent population history or the effects of endogamy on the Pakistani population. Here the authors examine the impact of the biraderi social stratification system on the population structure of individuals of British Pakistani ancestry in the Born in Bradford cohort.

    • Elena Arciero
    • , Sufyan A. Dogra
    •  & Hilary C. Martin

  • Article
    | Open Access

    Little is known about how human parental relatedness varied across ancient populations. Runs of homozygosity (ROH) in the offspring’s genome can give clues. Here, the authors present a method to identify ROH in ancient genomes and infer low rates of close kin unions across most ancient populations.

    • Harald Ringbauer
    • , John Novembre
    •  & Matthias Steinrücken

  • Article
    | Open Access

    Homozygosity mapping is a useful tool for identifying candidate mutations in recessive conditions, however application to next generation sequencing data has been sub-optimal. Here, the authors present AutoMap, which efficiently identifies runs of homozygosity in whole exome/genome sequencing data.

    • Mathieu Quinodoz
    • , Virginie G. Peter
    •  & Carlo Rivolta

  • Article
    | Open Access

    The prevalence of cardiometabolic diseases (CMDs) is increasing rapidly across Africa. Here, the authors investigate autozygosity in CMD-associated traits in over 10,000 sub-Saharan African individuals, showing these traits are influenced by sex-specific inbreeding depression and environmental interactions.

    • Francisco C. Ceballos
    • , Scott Hazelhurst
    •  & Michèle Ramsay

  • Article
    | Open Access

    Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

    • David W Clark
    • , Yukinori Okada
    •  & James F Wilson

  • Article
    | Open Access

    Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.

    • Loic Yengo
    • , Naomi R. Wray
    •  & Peter M. Visscher

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