Clonal selection

Clonal selection is a process proposed to explain how a single B or T cell that recognizes an antigen that enters the body is selected from the pre-existing cell pool of differing antigen specificities and then reproduced to generate a clonal cell population that eliminates the antigen.

Latest Research and Reviews

  • Research | | open

    For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 of the pre-selection antigen receptors are essential for the selection of MHC-restricted repertoire.

    • Jinghua Lu
    • , François Van Laethem
    • , Abhisek Bhattacharya
    • , Marco Craveiro
    • , Ingrid Saba
    • , Jonathan Chu
    • , Nicholas C. Love
    • , Anastasia Tikhonova
    • , Sergei Radaev
    • , Xiaoping Sun
    • , Annette Ko
    • , Tomer Arnon
    • , Eric Shifrut
    • , Nir Friedman
    • , Nan-Ping Weng
    • , Alfred Singer
    •  & Peter D. Sun
  • Research | | open

    The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX complex to act on two enhancer elements of the CD4 gene to control T cell lineage commitment in the thymus.

    • Satoshi Kojo
    • , Nighat Yasmin
    • , Sawako Muroi
    • , Mari Tenno
    •  & Ichiro Taniuchi
  • Research | | open

    The expression of CD4, a critical co-receptor providing T cell help in adaptive immunity, is finely tuned during development. Here the authors show that two enhancer elements, E4p and the newly-defined E4m, coordinate the expression and heritable demethylation of Cd4 in thymocytes but are dispensable for its sustained expression in peripheral T cells.

    • Priya D. Issuree
    • , Kenneth Day
    • , Christy Au
    • , Ramya Raviram
    • , Paul Zappile
    • , Jane A. Skok
    • , Hai-Hui Xue
    • , Richard M. Myers
    •  & Dan R. Littman
  • Research | | open

    Human Vδ2+ γδ T cells are thought to be an innate-like T-cell population. Here the authors show the Vδ2+ compartment contains both innate-like Vγ9+ and an adaptive Vγ9- subset that undergoes clonal expansion during viral infection and can infiltrate liver tissue.

    • Martin S. Davey
    • , Carrie R. Willcox
    • , Stuart Hunter
    • , Sofya A. Kasatskaya
    • , Ester B. M. Remmerswaal
    • , Mahboob Salim
    • , Fiyaz Mohammed
    • , Frederike J. Bemelman
    • , Dmitriy M. Chudakov
    • , Ye H. Oo
    •  & Benjamin E. Willcox
  • Research | | open

    Autoreactive T cells are removed during their development in the thymus through the functions of medullary thymic epithelial cells (mTEC) and dendritic cells (DC), a process termed negative selection. Here the authors show that mTEC-T cell crosstalk and lymphotoxin α signalling are essential for the proper recruitment of DCs into the thymus.

    • Noëlla Lopes
    • , Jonathan Charaix
    • , Oriane Cédile
    • , Arnauld Sergé
    •  & Magali Irla

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