Chromatin analysis

Definition

Chromatin analysis is the study of the structure or function of chromatin. Chromatin is made up of proteins (mainly histones) and genomic DNA packed inside the nuclei of eukaryotic cells; its architecture and chemical modifications affect genome structure, integrity and gene regulation.

Latest Research and Reviews

  • Research | | open

    • Pierre Luciano
    • , Jongcheol Jeon
    • , Abdessamad El-kaoutari
    • , Drice Challal
    • , Amandine Bonnet
    • , Mara Barucco
    • , Tito Candelli
    • , Frederic Jourquin
    • , Pascale Lesage
    • , Jaehoon Kim
    • , Domenico Libri
    •  & Vincent Géli
  • Research | | open

    Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing rapid, reversible manipulation of epigenetic states.

    • Simon M. G. Braun
    • , Jacob G. Kirkland
    • , Emma J. Chory
    • , Dylan Husmann
    • , Joseph P. Calarco
    •  & Gerald R. Crabtree
  • Research |

    The Omni-ATAC protocol improves the signal-to-background ratio in chromatin accessibility profiles and is suitable for a range of cell lines and primary cell types, as well as frozen tissue.

    • M Ryan Corces
    • , Alexandro E Trevino
    • , Emily G Hamilton
    • , Peyton G Greenside
    • , Nicholas A Sinnott-Armstrong
    • , Sam Vesuna
    • , Ansuman T Satpathy
    • , Adam J Rubin
    • , Kathleen S Montine
    • , Beijing Wu
    • , Arwa Kathiria
    • , Seung Woo Cho
    • , Maxwell R Mumbach
    • , Ava C Carter
    • , Maya Kasowski
    • , Lisa A Orloff
    • , Viviana I Risca
    • , Anshul Kundaje
    • , Paul A Khavari
    • , Thomas J Montine
    • , William J Greenleaf
    •  & Howard Y Chang
    Nature Methods 14, 959–962

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