Chemoprevention

Definition

Chemoprevention involves the use of chemical compounds or biologics to prevent or delay the development of a specific disease. For example, chemoprevention approaches are currently used in oncology to reduce the risk of cancer returning following surgery (known as secondary chemoprevention).

Latest Research and Reviews

  • Reviews |

    A number of breast lesions that are associated with an increased risk of breast cancer and/or represent true precursors of breast tumours are increasingly detected in population screening programmes. At present, the clinicopathological and molecular characteristics that defined the risk of breast cancer in women with these lesions are unknown; nevertheless, management strategies ranging from active surveillance to surgery with adjuvant radiotherapy and endocrine therapy can be planned based on the risk of breast cancer at the population level. Herein, the contemporary approaches to the diagnosis and management of high-risk breast lesions are comprehensively reviewed.

    • Monica Morrow
    • , Stuart J. Schnitt
    •  & Larry Norton
  • Reviews |

    Based on previous successes and failures, this Review discusses potential future directions for cancer prevention that include the use of genetic, proteomic and other molecular approaches to identify pathways that could be modified during cancer initiation. The use of immunotherapies for cancer prevention is also discussed.

    • Asad Umar
    • , Barbara K. Dunn
    •  & Peter Greenwald
    Nature Reviews Cancer 12, 835–848
  • Reviews |

    Lung cancer is the leading cause of cancer death in the world. Although smoking cessation will have the greatest impact on lung cancer development, chemoprevention could prove to be very effective. The authors discuss the principles of chemoprevention, including data from preclinical models, completed clinical trials and observational studies, and describe new treatments for novel targeted pathways and future chemopreventive efforts.

    • Robert L. Keith
    •  & York E. Miller
  • Research |

    Cancer 'chemoprevention' uses substances to reverse, suppress or prevent the initial phase of carcinogenesis or the progression of neoplastic cells to cancer cells. Here it is shown that treatment with TRAIL proteins and all-trans-retinyl acetate can cause the death, in vitro and in vivo, of premalignant cells deficient in the adenomatous polyposis coli gene. Normal cells are unaffected. Selectively eliminating premalignant tumour cells in this way is thus an effective method for chemoprevention.

    • Ling Zhang
    • , Xiaoyang Ren
    • , Eckhard Alt
    • , Xiaowen Bai
    • , Shaoyi Huang
    • , Zhengming Xu
    • , Patrick M. Lynch
    • , Mary P. Moyer
    • , Xian-Feng Wen
    •  & Xiangwei Wu
    Nature 464, 1058–1061

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