Central tolerance encompasses the mechanisms that render newly developing lymphocytes in primary lymphoid organs tolerant to self antigens. Developing B cells and T cells that react strongly to self antigens either undergo alteration of their antigen receptors, or face functional inactivation, deletion by apoptosis or programming into a suppressive phenotype.
Latest Research and Reviews
Research | | openScientific Reports 7, 43060
Research |Nature Immunology 17, 946–955