Featured
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Letter |
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
Through drug exposure, a rare, transient transcriptional program characterized by high levels of expression of known resistance drivers can get ‘burned in’, leading to the selection of cells endowed with a transcriptional drug resistance and thus more chemoresistant cancers.
- Sydney M. Shaffer
- , Margaret C. Dunagin
- & Arjun Raj
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Letter |
Single-cell messenger RNA sequencing reveals rare intestinal cell types
An algorithm that allows rare cell type identification in a complex population of single cells, based on single-cell mRNA-sequencing, is applied to mouse intestinal cells, revealing novel subtypes of enteroendocrine cells and showing that the Lgr5-expressing population consists of a homogenous stem cell population with a few rare secretory cells, including Paneth cells.
- Dominic Grün
- , Anna Lyubimova
- & Alexander van Oudenaarden
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Letter |
Single-cell chromatin accessibility reveals principles of regulatory variation
A single-cell method for probing genome-wide chromatin accessibility has been developed; the results provide insight into the relationship between cell-to-cell variation associated with specific trans-factors and cis-elements, as well insights into the relationship between chromatin accessibility and three-dimensional genome organization.
- Jason D. Buenrostro
- , Beijing Wu
- & William J. Greenleaf
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Letter |
A noisy linear map underlies oscillations in cell size and gene expression in bacteria
Quantification of single-cell growth over long periods of time in E. coli shows transient oscillations in cell size, with periods stretching across more than ten generations; a noisy negative feedback on cell-size control is proposed in which cells with a small initial size tend to divide later than cells with a large initial size with implications for the genetic and physiological processes required.
- Yu Tanouchi
- , Anand Pai
- & Lingchong You
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Letter |
Lineage correlations of single cell division time as a probe of cell-cycle dynamics
Precise measurement of cell-cycle duration in thousands of mammalian cells reveals correlations among cousin cells, but no such correlations between mother and daughter cells; recapitulating this finding using a deterministic model suggests that observed cellular heterogeneities in cell-cycle duration may be attributable to deterministic processes, and eventually be controlled.
- Oded Sandler
- , Sivan Pearl Mizrahi
- & Nathalie Q. Balaban
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News & Views |
The cost of feedback control
Noise in biochemical processes can compromise precision in cellular functions. An analysis involving information theory suggests that there is a strict limit to how far noise can be suppressed by feedback.
- Li Sun
- & Attila Becskei
Pairing of segmentation clock genes drives robust pattern formation
Functional roles for noise in genetic circuits