Research Highlight |
Featured
-
-
Article
| Open Access
Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography
Hierarchical phase-contrast tomography (HiP-CT) enables multiscale imaging of any region within an intact human organ down to cellular resolution. HiP-CT of five organ types revealed 3D morphological features in healthy and diseased tissue.
- C. L. Walsh
- , P. Tafforeau
- & P. D. Lee
-
Article |
Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
The combination of controlled three-dimensional assembly and electrical stimulation allows the maturation of stem cell–derived cardiomyocytes.
- Sara S Nunes
- , Jason W Miklas
- & Milica Radisic
-
Article |
Detection of histone modifications at specific gene loci in single cells in histological sections
A combination of in situ hybridization and a proximity ligation assay allows the visualization of histone modifications at single genomic loci with single-cell resolution in fixed tissue.
- Delphine Gomez
- , Laura S Shankman
- & Gary K Owens
-
News & Views |
Seeing is believing
Stabilization with a suction window permits in vivo imaging of the mouse lung vasculature with video-rate two-photon microscopy.
- Jahar Bhattacharya
-
News & Views |
Pacing lightly: optogenetics gets to the heart
Transfer of the light-activated cation channel channelrhodopsin-2 gene enables optical control of heart muscle membrane potential.
- Björn C Knollmann
-
Brief Communication |
Optogenetic control of heart muscle in vitro and in vivo
Stimulation of the light-activated cation channel channelrhodopsin-2 can depolarize heart muscle in vitro and in vivo, resulting in precise localized stimulation and constant prolonged depolarization of genetically targeted cardiomyocytes and cardiac tissue.
- Tobias Bruegmann
- , Daniela Malan
- & Philipp Sasse
