Calcium signalling

Definition

Calcium signalling is activated by calcium ions that are released from intracellular stores, or enter the cell via plasma membrane ion channels. Calcium is an important second messenger that regulates many cellular activities, including fertilisation, secretion, neurotransmission and cell migration.

Latest Research and Reviews

  • Research | | open

    STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1.

    • Sophia Maschalidi
    • , Paula Nunes-Hasler
    • , Clarissa R Nascimento
    • , Ignacio Sallent
    • , Valérie Lannoy
    • , Meriem Garfa-Traore
    • , Nicolas Cagnard
    • , Fernando E. Sepulveda
    • , Pablo Vargas
    • , Ana-Maria Lennon-Duménil
    • , Peter van Endert
    • , Thierry Capiod
    • , Nicolas Demaurex
    • , Guillaume Darrasse-Jèze
    •  & Bénédicte Manoury
  • Research | | open

    The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.

    • Julia J. Mack
    • , Thiago S. Mosqueiro
    • , Brian J. Archer
    • , William M. Jones
    • , Hannah Sunshine
    • , Guido C. Faas
    • , Anais Briot
    • , Raquel L. Aragón
    • , Trent Su
    • , Milagros C. Romay
    • , Austin I. McDonald
    • , Cheng-Hsiang Kuo
    • , Carlos O. Lizama
    • , Timothy F. Lane
    • , Ann C. Zovein
    • , Yun Fang
    • , Elizabeth J. Tarling
    • , Thomas Q. de Aguiar Vallim
    • , Mohamad Navab
    • , Alan M. Fogelman
    • , Louis S. Bouchard
    •  & M. Luisa Iruela-Arispe
  • Research | | open

    IP3 receptors mediate Ca2+ release from the endoplasmic reticulum. Here the authors show that only a small fraction of IP3 receptors initiate Ca2+ signals; these immobile IP3 receptors adjacent to the plasma membrane are optimally placed to control STIM1-dependent Ca2+ entry.

    • Nagendra Babu Thillaiappan
    • , Alap P. Chavda
    • , Stephen C. Tovey
    • , David L. Prole
    •  & Colin W. Taylor
  • Research | | open

    ATP11C is a flippase that uses ATP hydrolysis to translocate phospholipids at the plasma membrane. Here, the authors show that the activation of Ca2+-dependent protein kinase C increases ATP11C endocytosis thus downregulating phospholipid translocation.

    • Hiroyuki Takatsu
    • , Masahiro Takayama
    • , Tomoki Naito
    • , Naoto Takada
    • , Kazuya Tsumagari
    • , Yasushi Ishihama
    • , Kazuhisa Nakayama
    •  & Hye-Won Shin

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