Calcium and phosphate metabolic disorders articles from across Nature Portfolio

Calcium and phosphate metabolic disorders are disorders that are characterized by abnormalities in the processing of calcium or phosphate. These disorders can affect the absorption, transport, storage and use of these minerals. Examples include hypocalcaemia and hyperphosphataemia.

Latest Research and Reviews

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

β-Cell dysfunction is a hallmark of type 2 diabetes. Here, the authors show that trimethylamine N-oxide (TMAO (a microbiota metabolite)) induces β-cell dysfunction and type 2 diabetes in mice through NLRP3 inflammasome activation and calcium transients.
- Lijuan Kong
- Qijin Zhao
- Pingping Li
ResearchOpen Access21 Mar 2024 Nature Communications
Volume: 15, P: 2526
RANKL inhibition reduces lesional cellularity and Gα_s variant expression and enables osteogenic maturation in fibrous dysplasia
- Luis F. de Castro
- Jarred M. Whitlock
- Alison M. Boyce
ResearchOpen Access20 Feb 2024 Bone Research
Volume: 12, P: 10
A new perspective on intervertebral disc calcification—from bench to bedside
- Emanuel J. Novais
- Rajkishen Narayanan
- Makarand V. Risbud
ReviewsOpen Access22 Jan 2024 Bone Research
Volume: 12, P: 3
Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort
- Katharina Charlotte Reimer
- Jennifer Nadal
- Wolfram Gronwald
ResearchOpen Access20 Oct 2023 Bone Research
Volume: 11, P: 52
Removal of calciprotein particles from the blood using an adsorption column improves prognosis of hemodialysis miniature pigs
- Marina Miura
- Yutaka Miura
- Makoto Kuro-o
ResearchOpen Access12 Sept 2023 Scientific Reports
Volume: 13, P: 15026
The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling
- Na Liu
- Rui Li
- Shusen Wang
ResearchOpen Access14 Jul 2023 Cell Death Discovery
Volume: 9, P: 247

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News and Comment

Reply to “Can femoral head necrosis induced by steroid therapy in patients infected with coronaviruses be reversed?”
- Peixun Zhang
- Jiabao Ju
- Baoguo Jiang
CorrespondenceOpen Access07 Jan 2021 Bone Research
Volume: 9, P: 2
Efficacy of tenapanor in hyperphosphataemia
- Ellen F. Carney
Research Highlights27 Feb 2017 Nature Reviews Nephrology
Volume: 13, P: 194
Calcium–T2DM link strengthens
- David Holmes
Research Highlights26 Aug 2016 Nature Reviews Endocrinology
Volume: 12, P: 626
The perils of a falling PTH due to high dialysate calcium

New data suggest that a fall in parathyroid hormone (PTH) 12 months after initiating haemodialysis is associated with cardiovascular death at 12–24 months. The main independent predictor for the fall in PTH is a high dialysate calcium concentration, which might not only reduce PTH but also induce vascular calcification.
- Wei Chen
- David A. Bushinsky
News & Views21 Mar 2016 Nature Reviews Nephrology
Volume: 12, P: 264-266
Proteinuria increases phosphate retention

Research Highlights18 Nov 2014 Nature Reviews Nephrology
Volume: 11, P: 2
Role for Klotho and phosphate in cardiac remodelling

Research Highlights04 Nov 2014 Nature Reviews Nephrology
Volume: 10, P: 674

All News & Comment

Calcium and phosphate metabolic disorders articles from across Nature Portfolio

Latest Research and Reviews

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

RANKL inhibition reduces lesional cellularity and Gα_s variant expression and enables osteogenic maturation in fibrous dysplasia

A new perspective on intervertebral disc calcification—from bench to bedside

Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort

Removal of calciprotein particles from the blood using an adsorption column improves prognosis of hemodialysis miniature pigs

The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling

News and Comment

Reply to “Can femoral head necrosis induced by steroid therapy in patients infected with coronaviruses be reversed?”

Efficacy of tenapanor in hyperphosphataemia

Calcium–T2DM link strengthens

The perils of a falling PTH due to high dialysate calcium

Proteinuria increases phosphate retention

Role for Klotho and phosphate in cardiac remodelling

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