Calcitonin

Definition

Calcitonin is a peptide hormone that in humans is produced by thyroid cells. This hormone is involved in the metabolism of calcium and phosphate and acts to reduce blood levels of calcium and inhibit osteoclast activity in bone.

Latest Research and Reviews

  • Research | | open

    The regulatory role of calcitonin in bone homeostasis is well studied, yet its molecular activity is poorly understood. The authors show that calcitonin regulates bone cells function by inhibiting the osteoclast secretion of sphingosine 1-phosphate, a lipid mediator of osteoclast–osteoblast crosstalk.

    • Johannes Keller
    • , Philip Catala-Lehnen
    • , Antje K. Huebner
    • , Anke Jeschke
    • , Timo Heckt
    • , Anja Lueth
    • , Matthias Krause
    • , Till Koehne
    • , Joachim Albers
    • , Jochen Schulze
    • , Sarah Schilling
    • , Michael Haberland
    • , Hannah Denninger
    • , Mona Neven
    • , Irm Hermans-Borgmeyer
    • , Thomas Streichert
    • , Stefan Breer
    • , Florian Barvencik
    • , Bodo Levkau
    • , Birgit Rathkolb
    • , Eckhard Wolf
    • , Julia Calzada-Wack
    • , Frauke Neff
    • , Valerie Gailus-Durner
    • , Helmut Fuchs
    • , Martin Hrab[ebreve] de Angelis
    • , Susanne Klutmann
    • , Elena Tsourdi
    • , Lorenz C. Hofbauer
    • , Burkhard Kleuser
    • , Jerold Chun
    • , Thorsten Schinke
    •  & Michael Amling