Basophils

Basophils are circulating granular leukocytes that are characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes. Basophils are important in controlling multicellular parasite infections, but can also be involved in allergy.

Latest Research and Reviews

  • Research |

    Eosinophilic esophagitis (EoE) is characterized by esophageal eosinophilia, but the underlying mechanisms promoting eosinophil accumulation remain unclear. David Artis and his colleagues describe a new mouse model of EoE-like disease. The development of EoE-like disease is dependent on thymic stromal lymphopoietin (TSLP) and basophils, whereas inhibition of TSLP or depletion of basophils attenuates established disease. Moreover, individuals with EoE have increased TSLP expression and basophils in the esophagus, suggesting that the TSLP-basophil axis can be targeted in patients with EoE.

    • Mario Noti
    • , Elia D Tait Wojno
    • , Brian S Kim
    • , Mark C Siracusa
    • , Paul R Giacomin
    • , Meera G Nair
    • , Alain J Benitez
    • , Kathryn R Ruymann
    • , Amanda B Muir
    • , David A Hill
    • , Kudakwashe R Chikwava
    • , Amin E Moghaddam
    • , Quentin J Sattentau
    • , Aneesh Alex
    • , Chao Zhou
    • , Jennifer H Yearley
    • , Paul Menard-Katcher
    • , Masato Kubo
    • , Kazushige Obata-Ninomiya
    • , Hajime Karasuyama
    • , Michael R Comeau
    • , Terri Brown-Whitehorn
    • , Rene de Waal Malefyt
    • , Patrick M Sleiman
    • , Hakon Hakonarson
    • , Antonella Cianferoni
    • , Gary W Falk
    • , Mei-Lun Wang
    • , Jonathan M Spergel
    •  & David Artis
    Nature Medicine 19, 1005-1013
  • Research | | open

    Both dendritic cells and basophils have been shown to influence T helper 2 cell induction, however the relative importance of their roles remains unclear. Otsuka et al. find that basophils present hapten and peptide antigens to T cells, but are unable to present protein antigens in the absence of dendritic cells.

    • Atsushi Otsuka
    • , Saeko Nakajima
    • , Masato Kubo
    • , Gyohei Egawa
    • , Tetsuya Honda
    • , Akihiko Kitoh
    • , Takashi Nomura
    • , Sho Hanakawa
    • , Catharina Sagita Moniaga
    • , Bongju Kim
    • , Satoshi Matsuoka
    • , Takeshi Watanabe
    • , Yoshiki Miyachi
    •  & Kenji Kabashima
  • Research |

    The contribution of basophils to allergic and helminth immunity remains unclear. Locksley and colleagues use reporter strains and two-photon microscopy to demonstrate that basophils do not mediate T helper type 2 priming in vivo.

    • Brandon M Sullivan
    • , Hong-Erh Liang
    • , Jennifer K Bando
    • , Davina Wu
    • , Laurence E Cheng
    • , James K McKerrow
    • , Christopher D C Allen
    •  & Richard M Locksley
    Nature Immunology 12, 527-535

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