Bacterial genomics

Bacterial genomics is a scientific discipline that concerns the genome, encompassing the entire hereditary information, of bacteria. Bacterial genomics can, for example, be used to study bacterial evolution or outbreaks of bacterial infections.

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  • News and Views |

    The rapidly dividing bacterium Vibrio natriegens holds promise for transforming traditional molecular biology and biotechnology processes. New work demonstrates that CRISPR interference technology is a robust tool for rapid, genome-wide screens in V. natriegens, facilitating future bioengineering efforts.

    • Jonathan D. D’Gama
    •  & Matthew K. Waldor
    Nature Microbiology 4, 1071-1072
  • News and Views |

    The secondary metabolite cepacin A is the essential compound made by Burkholderia ambifaria needed for biocontrol of plant pathogens. In this organism, genes responsible for virulence and for cepacin A biosynthesis reside on different replicons, allowing for the engineering of avirulent mutants that retain their biocontrol properties.

    • Tom Coenye
    Nature Microbiology 4, 908-909
  • News and Views |

    Applying the principles of ‘omics’ to urinary tract infection opens up exciting diagnostic and management avenues. Urinary cell-free DNA can be used to gain new insight not only into the spectrum of pathogens present in host urine but also their likelihood to cause disease.

    • Rhana Hassan Zakri
    •  & Jonathon Olsburgh
  • News and Views |

    Genome-wide association studies and genetic analyses have identified a clinically prevalent alteration in the Mycobacterium tuberculosis genome that rewires bacterial propionate metabolism, conditionally reduces antibiotic killing without affecting minimum inhibitory concentrations, and may drive emergence of drug resistance.

    • Thomas Dick
    •  & Véronique Dartois
    Nature Microbiology 3, 971-972