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Bacterial adhesion is a process that allows bacteria to attach or adhere to other cells and surfaces. Adhesion is an important step for colonization of a new host or environment and can contribute to bacterial pathogenesis.
Staphylococcus aureus is a facultative pathogen that colonizes the human nares. In this Review, Peschel and colleagues discuss the mechanisms that are used by S. aureus to prevail in the human nose and the counter-strategies that are used by other commensals to interfere with its colonization.
Bacteria have to overcome many obstacles to invade the meninges from the bloodstream. This Review considers how extracellular pathogens such as Neisseria meningitides and Streptococcus pneumoniae bypass the blood–brain barriers, the understanding of which may lead to improved methods for delivering drugs into the brain.
Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli. Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction between the adhesin FimH and carbohydrate receptors.