B-cell receptor

Definition

The B-cell receptor (BCR) is an immunoglobulin molecule forming a type I transmembrane protein on the surface of B cells. The BCR transmits activatory signals into the B cell following its recognition of a specific antigen.

Latest Research and Reviews

  • Research | | open

    An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.

    • Wilton B. Williams
    • , Jinsong Zhang
    • , Chuancang Jiang
    • , Nathan I. Nicely
    • , Daniela Fera
    • , Kan Luo
    • , M. Anthony Moody
    • , Hua-Xin Liao
    • , S. Munir Alam
    • , Thomas B. Kepler
    • , Akshaya Ramesh
    • , Kevin Wiehe
    • , James A. Holland
    • , Todd Bradley
    • , Nathan Vandergrift
    • , Kevin O. Saunders
    • , Robert Parks
    • , Andrew Foulger
    • , Shi-Mao Xia
    • , Mattia Bonsignori
    • , David C. Montefiori
    • , Mark Louder
    • , Amanda Eaton
    • , Sampa Santra
    • , Richard Scearce
    • , Laura Sutherland
    • , Amanda Newman
    • , Hilary Bouton-Verville
    • , Cindy Bowman
    • , Howard Bomze
    • , Feng Gao
    • , Dawn J. Marshall
    • , John F. Whitesides
    • , Xiaoyan Nie
    • , Garnett Kelsoe
    • , Steven G. Reed
    • , Christopher B. Fox
    • , Kim Clary
    • , Marguerite Koutsoukos
    • , David Franco
    • , John R. Mascola
    • , Stephen C. Harrison
    • , Barton F. Haynes
    •  & Laurent Verkoczy
  • Research | | open

    Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria infection.

    • Ben S. Wendel
    • , Chenfeng He
    • , Mingjuan Qu
    • , Di Wu
    • , Stefany M. Hernandez
    • , Ke-Yue Ma
    • , Eugene W. Liu
    • , Jun Xiao
    • , Peter D. Crompton
    • , Susan K. Pierce
    • , Pengyu Ren
    • , Keke Chen
    •  & Ning Jiang
  • Research |

    B-cell VH region repertoire sequencing of eight anatomical sites in six human donors reveals distinct networks of clone distribution.

    • Wenzhao Meng
    • , Bochao Zhang
    • , Gregory W Schwartz
    • , Aaron M Rosenfeld
    • , Daqiu Ren
    • , Joseph J C Thome
    • , Dustin J Carpenter
    • , Nobuhide Matsuoka
    • , Harvey Lerner
    • , Amy L Friedman
    • , Tomer Granot
    • , Donna L Farber
    • , Mark J Shlomchik
    • , Uri Hershberg
    •  & Eline T Luning Prak
    Nature Biotechnology 35, 879–884
  • Research |

    Combined studies in MYC-driven mouse lymphomas and human Burkitt lymphoma unravel an essential role for the B-cell antigen receptor in the control of tumour B-cell fitness both in vitro and in vivo, with possible biological and clinical implications.

    • Gabriele Varano
    • , Simon Raffel
    • , Martina Sormani
    • , Federica Zanardi
    • , Silvia Lonardi
    • , Christin Zasada
    • , Laura Perucho
    • , Valentina Petrocelli
    • , Andrea Haake
    • , Albert K. Lee
    • , Mattia Bugatti
    • , Ulrike Paul
    • , Eelco Van Anken
    • , Laura Pasqualucci
    • , Raul Rabadan
    • , Reiner Siebert
    • , Stefan Kempa
    • , Maurilio Ponzoni
    • , Fabio Facchetti
    • , Klaus Rajewsky
    •  & Stefano Casola
    Nature 546, 302–306
  • Research | | open

    Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome.

    • Claudia Minici
    • , Maria Gounari
    • , Rudolf Übelhart
    • , Lydia Scarfò
    • , Marcus Dühren-von Minden
    • , Dunja Schneider
    • , Alpaslan Tasdogan
    • , Alabbas Alkhatib
    • , Andreas Agathangelidis
    • , Stavroula Ntoufa
    • , Nicholas Chiorazzi
    • , Hassan Jumaa
    • , Kostas Stamatopoulos
    • , Paolo Ghia
    •  & Massimo Degano

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