B-2 cells

B-2 cells are a subtype of B cell. They form part of the adaptive immune response and mediate humoral immunity. B 2 cells can produce high-affinity antibodies and generate immunological memory. B-2 cells are often used synonymously with classical B cells.

Latest Research and Reviews

  • Research | | open

    Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells, yet modulates, in p53-independent manners, the survival and differentiation of mature B cells.

    • Ludivine C. Litzler
    • , Astrid Zahn
    • , Alexandre P. Meli
    • , Steven Hébert
    • , Anne-Marie Patenaude
    • , Stephen P. Methot
    • , Adrien Sprumont
    • , Thérence Bois
    • , Daisuke Kitamura
    • , Santiago Costantino
    • , Irah L. King
    • , Claudia L. Kleinman
    • , Stéphane Richard
    •  & Javier M. Di Noia
  • Research | | open

    Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from the germinal centre, for rapid expansion and the induction of B memory responses.

    • Imogen Moran
    • , Akira Nguyen
    • , Weng Hua Khoo
    • , Danyal Butt
    • , Katherine Bourne
    • , Clara Young
    • , Jana R. Hermes
    • , Maté Biro
    • , Gary Gracie
    • , Cindy S. Ma
    • , C. Mee Ling Munier
    • , Fabio Luciani
    • , John Zaunders
    • , Andrew Parker
    • , Anthony D. Kelleher
    • , Stuart G. Tangye
    • , Peter I. Croucher
    • , Robert Brink
    • , Mark N. Read
    •  & Tri Giang Phan
  • Research | | open

    Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter levels.

    • Anna S. Wilhelmson
    • , Marta Lantero Rodriguez
    • , Alexandra Stubelius
    • , Per Fogelstrand
    • , Inger Johansson
    • , Matthew B. Buechler
    • , Steve Lianoglou
    • , Varun N. Kapoor
    • , Maria E. Johansson
    • , Johan B. Fagman
    • , Amanda Duhlin
    • , Prabhanshu Tripathi
    • , Alessandro Camponeschi
    • , Bo T. Porse
    • , Antonius G. Rolink
    • , Hans Nissbrandt
    • , Shannon J. Turley
    • , Hans Carlsten
    • , Inga-Lill Mårtensson
    • , Mikael C. I. Karlsson
    •  & Åsa Tivesten
  • Research | | open

    IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice.

    • Mei Yu
    • , Yuhong Chen
    • , Hu Zeng
    • , Yongwei Zheng
    • , Guoping Fu
    • , Wen Zhu
    • , Ulrich Broeckel
    • , Praful Aggarwal
    • , Amy Turner
    • , Geoffrey Neale
    • , Cliff Guy
    • , Nan Zhu
    • , Hongbo Chi
    • , Renren Wen
    •  & Demin Wang

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