Autoinflammatory syndrome

Autoinflammatory syndrome refers to a disorder characterized by recurrent episodes of systemic inflammation in the apparent absence of pathogens, autoantibodies or self-reactive lymphocytes. These disorders are caused by dysfunction of the innate immune system. Examples of such disorders include Behçet's disease, Familial Mediterranean Fever and Cryopyrin-Associated Periodic Syndrome.

Latest Research and Reviews

News and Comment

  • News and Views |

    Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?

    • Keith B. Elkon
  • News and Views |

    Stimulator of interferon genes (STING), an important component of the cytosolic DNA sensing pathway, is an attractive therapeutic target for ameliorating interferon-driven systemic inflammation. New findings are shedding light on how STING functions and on a strategy to target STING therapeutically.

    • Carolina Uggenti
    •  & Yanick J. Crow
  • Research Highlights |

    Thirumala-Devi Kanneganti describes a 2002 study by Jürg Tschopp and colleagues that first described the multiprotein, caspase-activating inflammasome complex that drives the maturation and secretion of IL-1β.

    • Thirumala-Devi Kanneganti
  • News and Views |

    A study of polymorphisms in the sensor IFIH1 exposes the evolutionary trade-off between a robust antiviral type I interferon response and the risk of interferon-mediated inflammation.

    • Erika Della Mina
    • , Mathieu P Rodero
    •  & Yanick J Crow
    Nature Immunology 18, 708-709