Asymmetric synthesis

Asymmetric synthesis is a method for preparation of chemical compounds which aims to bias the synthesis in favour of producing one stereoisomer over another stereoisomer. Stereoisomers are molecules with the same connectivity of atoms, but with different arrangements of atoms in three-dimensional space, and can have dramatically different properties from one another.

Latest Research and Reviews

News and Comment

  • News and Views |

    The preparation of three-dimensional frameworks with multiple stereocentres from simple acyclic hydrocarbons represents a challenging transformation. Now, starting from simple and readily available reagents, formation of these complex targets can be achieved in just three catalytic transformations with high levels of stereocontrol.

    • Laura Castoldi
    •  & Vittorio Pace
    Nature Chemistry 10, 1081-1082
  • News and Views |

    The palladium-catalysed cross-coupling of aryl- or alkenylboronates and aryl halides has proved phenomenally successful for the formation of Csp2–Csp2 bonds. Now, an alternative non-transition-metal-mediated coupling using similar reactants has been reported for the stereo-controlled formation of Csp2–Csp3 bonds.

    • Ho-Yan Sun
    •  & Dennis G. Hall
    Nature Chemistry 6, 561-562
  • News and Views |

    A combination of catalytic asymmetric diboration of terminal alkenes and Suzuki–Miyaura cross-coupling has been exploited in the synthesis of a variety of important medicinal agents. The process overcomes a number of problems in the application of these important catalytic processes.

    • Rian D. Dewhurst
    •  & Todd B. Marder
    Nature Chemistry 6, 279-280