Asymmetric catalysis

Asymmetric catalysis is a type of catalysis in which a chiral catalyst directs the formation of a chiral compound such that formation of one particular stereoisomer is favoured. Since the catalyst is not consumed in this process it may be used in a substoichiometric quantity – potentially improving efficiency and avoiding waste.

Latest Research and Reviews

News and Comment

  • News and Views |

    Optimization of catalytic stereoselectivity for new substrates often requires a time consuming experimental process, and high-accuracy molecular modelling remains intractable for comprehensive virtual screening. Now, highly enantioselective rhodium hydrogenation catalysts have been identified using a rapid computational transition-state analysis protocol and then experimentally verified.

    • Daniel H. Ess
  • Research Highlights |

    Iridium chelates are attractive catalysts for asymmetric transfer hydrogenation. The mode through which a chelating ligand binds iridium turns out to have a striking effect on catalytic activity and enantioselectivity.

    • Andrew Bissette
  • Editorial |

    The field of organic synthesis has benefited from a greater understanding of organometallic and coordination chemistry, and the applications of homogeneous catalysts continue to impress.

  • News and Views |

    The need for new single enantiomer drug substances helps drive the development of new asymmetric catalytic synthetic methods. A new enantioconvergent process enabled by an ionization racemization mechanism allows a hydrogenative route to chiral compounds with two stereocentres.

    • Jessica A. Griswold
    •  & Jeffrey S. Johnson
    Nature Catalysis 1, 379-380