Antimicrobial resistance

Definition

Antimicrobial resistance is the ability of microorganisms such as bacteria, fungi or protozoans to grow despite exposure to antimicrobial substances designed to inhibit their growth. Microbes can evolve antimicrobial resistance when, for example, populations are subjected to selective pressure through drug use in medicine.

Latest Research and Reviews

  • Research | | open

    Mechanisms underlying increasing artemisinin resistance of Plasmodium in Southeast Asia remain unclear. Here, Zhu et al. integrate TWAS, GWAS and eQTL analyses for 773 P. falciparum isolates and identify genetic and transcriptomic backgrounds to artemisinin resistance.

    • Lei Zhu
    • , Jaishree Tripathi
    • , Frances Maureen Rocamora
    • , Olivo Miotto
    • , Rob van der Pluijm
    • , Till S. Voss
    • , Sachel Mok
    • , Dominic P. Kwiatkowski
    • , François Nosten
    • , Nicholas P. J. Day
    • , Nicholas J. White
    • , Arjen M. Dondorp
    • , Zbynek Bozdech
    • , Aung Pyae Phyo
    • , Elizabeth A. Ashley
    • , Frank Smithuis
    • , Khin Lin
    • , Kyaw Myo Tun
    • , M Abul Faiz
    • , Mayfong Mayxay
    • , Mehul Dhorda
    • , Nguyen Thanh Thuy-Nhien
    • , Paul N. Newton
    • , Sasithon Pukrittayakamee
    • , Tin M. Hlaing
    • , Tran Tinh Hien
    •  & Ye Htut
  • Research |

    Development of a structure-based method to predict potential ARDs present in human metagenomes indicates that resistance genes are rarely transferred within the human gut, and that individuals can be clustered into resistotypes.

    • Etienne Ruppé
    • , Amine Ghozlane
    • , Julien Tap
    • , Nicolas Pons
    • , Anne-Sophie Alvarez
    • , Nicolas Maziers
    • , Trinidad Cuesta
    • , Sara Hernando-Amado
    • , Irene Clares
    • , Jose Luís Martínez
    • , Teresa M. Coque
    • , Fernando Baquero
    • , Val F. Lanza
    • , Luis Máiz
    • , Tiphaine Goulenok
    • , Victoire de Lastours
    • , Nawal Amor
    • , Bruno Fantin
    • , Ingrid Wieder
    • , Antoine Andremont
    • , Willem van Schaik
    • , Malbert Rogers
    • , Xinglin Zhang
    • , Rob J. L. Willems
    • , Alexandre G. de Brevern
    • , Jean-Michel Batto
    • , Hervé M. Blottière
    • , Pierre Léonard
    • , Véronique Léjard
    • , Aline Letur
    • , Florence Levenez
    • , Kevin Weiszer
    • , Florence Haimet
    • , Joël Doré
    • , Sean P. Kennedy
    •  & S. Dusko Ehrlich
    Nature Microbiology 4, 112–123
  • Reviews |

    Resistance to antimicrobials and pesticides — collectively, biocides — undermines human health and food production. This Review assesses options for governing and promoting susceptibility to biocides to remain within the planet’s safe operating space.

    • Peter Søgaard Jørgensen
    • , Athena Aktipis
    • , Zachary Brown
    • , Yves Carrière
    • , Sharon Downes
    • , Robert R. Dunn
    • , Graham Epstein
    • , George B. Frisvold
    • , David Hawthorne
    • , Yrjö T. Gröhn
    • , Govind Tikaramsa Gujar
    • , Dušan Jasovský
    • , Eili Y. Klein
    • , Franziska Klein
    • , Guillaume Lhermie
    • , David Mota-Sanchez
    • , Celso Omoto
    • , Maja Schlüter
    • , H. Morgan Scott
    • , Didier Wernli
    •  & Scott P. Carroll
  • Reviews |

    Bacterial membrane vesicles can transfer material between cells and function as decoys for antibiotics and phages. This Review provides an overview of different vesicle types, including classic outer-membrane vesicles and newly identified types that are induced by phage-derived autolysins.

    • Masanori Toyofuku
    • , Nobuhiko Nomura
    •  & Leo Eberl

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