Antimicrobial resistance articles within Nature

Featured

  • Article |

    We use a whole-cell accumulation assay to assess the ability of non-antibiotic, structurally diverse small molecules to accumulate in Pseudomonas aeruginosa, with potential application in developing drugs to target this pathogen.

    • Emily J. Geddes
    • , Morgan K. Gugger
    •  & Paul J. Hergenrother

  • Article
    | Open Access

    Cryo-electron microscopy structures of Staphylococcus aureus BlaR1 reveal dynamic signalling states regulating broad spectrum β-lactam antibiotic resistance through cleavage of the transcriptional repressor BlaI and induced expression of the β-lactamase blaZ and the β-lactam-resistant cell-wall transpeptidase mecA.

    • J. Andrew N. Alexander
    • , Liam J. Worrall
    •  & Natalie C. J. Strynadka

  • Article
    | Open Access

    Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated to be clinically useful against COVID-19, but viral resistance to the drug was found to arise readily via multiple pathways in vitro.

    • Sho Iketani
    • , Hiroshi Mohri
    •  & David D. Ho

  • Article |

    Different pairs of antibiotics show qualitatively different bacterial clearance interactions—some pairs show reciprocal suppression whereby the drug mixture efficacy is weaker than the individual drugs alone, and the clearance efficacy decreases as more drugs are added.

    • Viktória Lázár
    • , Olga Snitser
    •  & Roy Kishony

  • Article
    | Open Access

    Methicillin-resistant strains of Staphylococcus aureus appeared in European hedgehogs in the pre-antibiotic era as a co-evolutionary adaptation to antibiotic-producing dermatophytes and have spread within the local hedgehog populations and between hedgehogs and secondary hosts.

    • Jesper Larsen
    • , Claire L. Raisen
    •  & Anders R. Larsen

  • Article |

    The microbiota of centenarians (aged 100 years and older) comprise gut microorganisms that are capable of generating unique secondary bile acids, including isoallolithocholic acid, a bile acid with potent antimicrobial effects against Gram-positive—but not Gram-negative—multidrug-resistant pathogens.

    • Yuko Sato
    • , Koji Atarashi
    •  & Kenya Honda

  • Article |

    An analysis of bacterial community structure and antibiotic resistance gene content of interconnected human faecal and environmental samples from two low-income communities in Latin America was carried out using a combination of functional metagenomics, 16S sequencing and shotgun sequencing; resistomes across habitats are generally structured along ecological gradients, but key resistance genes can cross these boundaries, and the authors assessed the usefulness of excreta management protocols in the prevention of resistance gene dissemination.

    • Erica C. Pehrsson
    • , Pablo Tsukayama
    •  & Gautam Dantas

  • Article |

    From a new species of β-proteobacteria, an antibiotic called teixobactin that does not generate resistance has been characterized; the antibiotic has two different lipid targets in different bacterial cell wall synthesis components, which may explain why resistance was not observed.

    • Losee L. Ling
    • , Tanja Schneider
    •  & Kim Lewis

  • Letter |

    Functional metagenomic selections for resistance to 18 antibiotics in 18 different soils reveal that bacterial community composition is the primary determinant of soil antibiotic resistance gene content.

    • Kevin J. Forsberg
    • , Sanket Patel
    •  & Gautam Dantas

  • Outlook |

    Combinations of anti-TB drugs are difficult to overcome because they attack Mycobacterium tuberculosis in different ways.

    • Amy Maxmen

  • Comment |

    Frank Aarestrup explains how he helped Denmark to cut the use of antibiotics in its livestock by 60%, and calls on the rest of the world to follow suit.

    • Frank Aarestrup

  • Letter |

    Five current human African trypanosomiasis drugs are used for genome-scale RNA interference target sequencing screens in Trypanosoma brucei, and reveal the transporters, organelles, enzymes and metabolic pathways that function to facilitate antitrypanosomal drug action.

    • Sam Alsford
    • , Sabine Eckert
    •  & David Horn

  • Outlook |

    Antiviral treatments are a critical component of an effective healthcare response to influenza, but drug resistance to the treatment-of-choice has public health officials searching for other options.

    • Roxanne Palmer

  • Outlook |

    The hepatitis C virus is endemic among injection drug users, who could harbour treatment-resistant viruses. We need to adapt to this reality, says Diana Sylvestre

    • Diana Sylvestre

  • News & Views |

    Emerging resistance to existing antimalarial drugs could nullify efforts to eliminate this deadly disease. The discovery of thousands of agents active against malaria parasites offers hope for developing new drugs.

    • David A. Fidock

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