Amoeboid migration


Amoeboid migration is a mode of rapid motility that is driven by actin-rich pseudopods, hydrostatically-generated blebs and a highly-contractile uropod, and is characterized by weak or absent adhesion to the substratum and little or no extracellular matrix proteolysis. The Dictyostelium amoeba, and lymphocytes, leukocytes, dendritic and cancer cells exhibit amoeboid motility.

Latest Research and Reviews

  • Research |

    Miao et al. show through imaging and mathematical simulations that changing the activation thresholds in an excitable PIP2–Ras–Rap signal transduction network can alter the types of protrusions formed in migrating Dictyostelium cells.

    • Yuchuan Miao
    • , Sayak Bhattacharya
    • , Marc Edwards
    • , Huaqing Cai
    • , Takanari Inoue
    • , Pablo A. Iglesias
    •  & Peter N. Devreotes
    Nature Cell Biology 19, 329–340
  • Research |

    Sahai and colleagues delineate a pathway through which components of the STRIPAK complex promote amoeboid cancer cell migration by regulating the linkage of the actomyosin network to the plasma membrane.

    • Chris D. Madsen
    • , Steven Hooper
    • , Melda Tozluoglu
    • , Andreas Bruckbauer
    • , Georgina Fletcher
    • , Janine T. Erler
    • , Paul A. Bates
    • , Barry Thompson
    •  & Erik Sahai
  • Research |

    Two-photon intravital imaging is used here to define the regulation of interstitial neutrophil migration at local sites of cell death upon sterile tissue injury and infection; leukotriene B4 (LTB4) is shown to act between neutrophils as a signal relay molecule that acts to enhance the radius of neutrophil recruitment within the inflamed interstitium, and also to control, in concert with integrin receptors, dense neutrophil clustering for tight wound seal formation.

    • Tim Lämmermann
    • , Philippe V. Afonso
    • , Bastian R. Angermann
    • , Ji Ming Wang
    • , Wolfgang Kastenmüller
    • , Carole A. Parent
    •  & Ronald N. Germain
    Nature 498, 371–375
  • Research |

    Migrating cancer cells are round or elongated, and it is thought that the differently shaped cells invade surrounding tissue using different mechanisms. Here, Orgaz et al. show that the round cells secrete matrix metalloproteinases, which allow them to degrade surrounding connective tissue more effectively than elongated cells.

    • Jose L. Orgaz
    • , Pahini Pandya
    • , Rimple Dalmeida
    • , Panagiotis Karagiannis
    • , Berta Sanchez-Laorden
    • , Amaya Viros
    • , Jean Albrengues
    • , Frank O. Nestle
    • , Anne J. Ridley
    • , Cedric Gaggioli
    • , Richard Marais
    • , Sophia N. Karagiannis
    •  & Victoria Sanz-Moreno