Aldosterone is a hormone produced in the adrenal gland. This steroid molecule, derived from cholesterol, promotes retention of sodium and water and lowers the levels of potassium in the blood through many mechanisms, including action on the mineralocorticoid receptors in the kidneys. It plays a central role in the regulation of blood pressure.
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Research Highlights |Nature Reviews Nephrology 12, 316
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Dual inhibitory action on aldosterone by combined angiotensin receptor antagonism and neprilysin inhibitionHypertension Research 39, 753–755
Research Highlights |Nature Reviews Nephrology 11, 567
Comments and Opinion |Hypertension Research 38, 314–316