The regulation of intracellular Ca2+ compartmentalization
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The regulation of intracellular Ca2+ compartmentalization
Calcium enters the cell via receptors in the cell membrane. The largest calcium store in cells is found in the endoplasmic reticulum/sarcoplasmic reticulum, where CRT and other calcium binding proteins like calsequestrin bind calcium. CRT is responsible for 50% of calcium binding in the endoplasmic reticulum.
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Calreticulin is a protein with many roles, including calcium regulation and helping other proteins fold. How did scientists discover calreticulin and its functions?
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