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January 27, 2011 | By:  Dave Deriso
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This Is Your Brain on Acid

An artist was given 100ug of LSD and a box of crayons during an experiment run by the once-groovy US government, circa 1950. Over the course of his eight-hour trip, he was asked to render several drawings of his experimenter, a rather serious-looking psychiatrist. Below, scans of the actual drawings depict a journey that, at its peak, transformed the artist's perceptual grip on the world into cognitive jazz.






The first question that a psychologist may ask is, "Was that ethical?," and if that psychologist is from California, "Can I try it too?" The second question is "What do his drawings represent about his thinking and did he actually see the world differently?" A neuroscientist may reply that LSD blocks serotonin 2A receptors and increases glutamate only in higher visual areas such as layers IV and V of the visual system. Thus, the artist likely perceived shapes and patterns normally but had disruptions in color perception, mimicking the crossing of senses (cross-modal integration) seen in synesthesia. Looking at the renderings above, it does appear that the basic shapes and patterns were properly reproduced, but something else is off — something more abstract. The computational neuroscientist would view this as a transformation, where a visual input is being transformed by an altered complex circuit, and ask, "What does this alteration teach us about that complex network, and can we model and reproduce some part of the altered sensory-perception transformation?" Such an idea, that the sensation is not leading to perception in a linear way, feeds the philosopher, who may beg the most profound question yet, "If reality is so profoundly subjective, how can you argue with someone who sees the world differently; is it even possible to be right about anything: religion, politics, or even philosophy?"

That's precisely what makes the brain so artistic, its ability to make a fine shrimp gumbo out of a few sensory ingredients. Even more interesting is its ability to hazard sharing that unique flavor by means of, and often against the limitations of, language. Such a curiosity brings us squarely to the purpose of this blog: to peer into that fine, fine shrimp gumbo we call a mind through the spectacles of these unique perspectives and see if we can gain a slightly larger window of the cognitive recipe.

If you're wondering about me, just know that I thoroughly enjoy cooking fine seafood dishes, playing jazz, and pondering all of the open questions about the mind and philosophy left for us to answer. Perhaps, if you've found yourself reading this, you are asking these same questions too.

5 Comments
Comments
January 28, 2011 | 02:07 AM
Posted By:  Dave Deriso
Great video Ilona! Agreed, 5HT effects auditory and visual perception. In general, LSD also can cause integration (or interference) between these senses so that the two affect each other! Interesting cultural link to the 60s-70s when LSD emerged in the art and music scene. Check out the Greatful Dead's wall of sound: http://www.prosounduniverse.com/sitebuilder/images/wall2-422x261.jpg
January 28, 2011 | 12:38 AM
Posted By:  Ilona Miko
oh yeah, and seconding khalil -- auditory respones are influenced heavily by serotonin-affecting drugs (all kinds). i just wanted to mention that before everyone starts to think serotonin-affecting drugs change only visual perception....our ears are windows to the world as well!
January 28, 2011 | 12:33 AM
Posted By:  Ilona Miko
terrific, love the visual. makes me wonder what pablo picassio was eating for lunch? here is another visual for everyone, this time on video: a housewife takes an LSD trip, http://www.youtube.com/watch?v=V5d4wWGK4Ig
January 27, 2011 | 07:44 PM
Posted By:  Khalil A. Cassimally
"transformed the artist's perceptual grip on the world into cognitive jazz." More into cognitive rock and roll if you ask me.
January 27, 2011 | 06:05 PM
Posted By:  Taylor Burns
Not sure about the others, but the last image in that sequence screams hangover. And I would be most inclined to buy the 5th one in, when he was probably at the peak of an acid trip. A lucrative muse, I suppose.
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