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Scientific American

April 1, 2000

1 min read

Building a Brainier Mouse

By genetically engineering a smarter than average mouse, scientists have assembled some of the central molecular components of learning and memory

By Joe Z. Tsien

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JOE Z. TSIEN has been an assistant professor in the department of molecular biology at Princeton University since 1997. He came to the U.S. in 1986 after graduating from East China Normal University in Shanghai and working for two years as an instructor at East China University of Science and Technology in Shanghai. He received his Ph.D. in biochemistry and molecular biology in 1990 from the University of Minnesota. He has consulted for several biotechnology companies seeking to develop therapies for age-related memory disorders. The Doogie mouse was a hit in his seven-year-old son's class during show-and-tell.

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Scientific American Magazine Vol 282 Issue 4This article was originally published with the title “Building a Brainier Mouse” in Scientific American Magazine Vol. 282 No. 4 ()
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