Presentation of a symmetric arterial template developed from three-dimensional time-of-flight magnetic resonance angiography, delineating the arterial territories of the neonatal brain map. See the article by Núñez et al. on page 1231.

Anand et al. found that concentrations of cortisol in hair were higher in black children than in those of other ethnicities, indicating the presence of more stressors in early life. Public health measures to reduce disparities between races should take into consideration the long-term effects of chronic stress in early life. See the article on page 1119.

Busch et al. identified potential diagnostic and therapeutic targets in immune cells found in the intestinal mucosa of children with inflammatory bowel disease (see page 839). In an accompanying Comment, Vitale and Strisciuglio examine the impact of this work (page 805).

In assessing the presence of cervical ribs and abnormal vertebral spine patterns in 367 children with esophageal atresia, anorectal malformations, or both, Schut et al. found that they frequently appear together. See the article on page 773.

Using organ-donor infant lung tissues, Wang et al. developed a method for growing and differentiating primary pediatric human lung epithelial cells that can model pediatric airway epithelium for both developmental aspects and pediatric disease mechanisms. See the article on page 511.

Preventing disease in the 21st century is about preventing not only disease in children but the pediatric conditions that have a lifelong impact on health.  There is something in this issue for everyone!  The cover image represents the health impacts of global climate change, arguably the most important challenge of our times. Credit: Centers for Disease Control and Prevention (https://www.cdc.gov/climateandhealth/effects).

Using data from 7863 children from the Generation R study, van Ingen et al. discovered that both gender and breastfeeding influence the risk of developing acute otitis media. See the article on page 163.