Pulmonary hypertension frequently accompanies bronchopulmonary dysplasia in preterm infants. The cover image shows echocardiography features associated with pulmonary hypertension. In their review in this issue, Giesinger et al. describe controversies surrounding approaches to diagnosis and management of this condition in preterm infants. See the article on page 901.

Bronchopulmonary dysplasia is a common long-term consequence of prematurity. Using a rat model, Vaidya et al. found that the expression of CCN1, a cysteine-rich protein member of the CCN family of matricellular proteins, was downregulated by hyperoxia. Intraperitoneal administration of CCN1 reduced measures of pulmonary inflammation, vascular remodeling, and right ventricular hypertrophy, and increased alveolar and vascular development. See the article on page 863.

Phillips et al. performed high-resolution magnetic resonance and diffusion tensor imaging of 3.5- to 4-year-old former preterm infants who had received erythropoiesis-stimulating agents (ESAs). The images were compared with those from preterm infants who had not received ESA and normal healthy controls. The authors found that ESA had long-term effects on brain development. See the article on page 685.

De Cock and colleagues report that early life exposure to endocrine-disrupting chemicals impacts thyroid-stimulating hormone levels in newborns. See the article on page 429.

Barnett et al. investigated the effect of low birth weight secondary to maternal malnourishment on kidney development and function compared with normal-weight controls. Their striking findings include reductions in glomeruli volume, renal perfusion, and glomerular filtration rate. See the article on page 340.

Staub et al. found that moderate preterm birth and invasive or noninvasive respiratory support decreased glomerular capillarization but not glomerular architecture in the lamb kidney. This effect may have adverse consequences for renal function in later childhood and adulthood. See the article on page 93.