Intestinal macrophages undergo inflammatory activation in necrotizing enterocolitis. See the article by MohanKuma et al. on page 951. Cover design by Erin Dewalt.

Tam et al. examined the association between postnatal fatty acid levels and measures of brain injury and development. See p 723.

Representative small-intestine histology slides showing necrotizing enterocolitis lesions induced in neonatal mice that were (clockwise from top left) breastfed or treated with formula and stress, lipopolysaccharide, or polyinosinic:polycytidylic acid. See the article on page 596. Cover design by Erin Dewalt.

Lewis et al. evaluated probiotic products to determine the accuracy of the claims on their labels. See p 445.

Grossi and colleagues assessed the frequency of 27 potential risk factors for autism during pregnancy and the peri-postnatal period. See the article on page 339. Cover design by Erin Dewalt.

The reviews in this special issue delve into social factors affecting modern pediatric health, including epigenetics, socioeconomics, and absence of child care. Cover design by Erin Dewalt.