Abstract

Pediatric Research (1974) 8, 384–384; doi:10.1203/00006450-197404000-00262

MATHEMATIC MODELING OF ROSE BENGAL KINETICS: DIAGNOSTIC AID IN NEONATAL OBSTRUCTIVE HEPATIC DISEASE

Charles E Mize1, Shelley I Saffer1 and Stephen A Szygenda1

1Univ. Tex. Health Sci. Ctr. (Southwestern), Dept. of Ped. & Comp. Sci., Dallas

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Abstract

Rose Bengal transport through the hepatobiliary system has been modeled as a stochastic process, with a computer-aided simulation program to generate the model's parameters from kinetic data in infants with obstructive jaundice. Blood, urine, liver & fecal compartments are the key model features, and the percentages of Rose Bengal transferred (transfer parameters) among these compartments over a period of time are found. This system's advantages are l)use of maximum information content of 131-l-Rose Bengal data (urine and stool appearance, plus plasma decay), b)analysis of less data than needed in classic compartmental analysis, and c)subclassification of disease not otherwise available presurgically. The solutions generated include the expected hours (before ending up in urine or feces) in (l)blood or (2)liver, and the probability that Rose Bengal will eventually terminate in (3) urine or (4) feces. Further information derives from ratios of the transfer parameters, e.g. (5)p(liver right arrow blood)/p(liver right arrow feces) For example:

The model provides results agreeing with pathologic status confirmed by laparotomy/cholangiogram and/or clinical course.