Background: Experimental total liquid ventilation (TLV) with perfluorocarbon (PFC) supports gas exchange, but mechanics of liquid breathing are unknown yet.
Aim: To develop a system for measurement of lung mechanics during TLV.
Subjects: Normal rats kept on TLV.
Interventions: Rats were managed by a gravity-assisted TLV circuit with a servocontrolled temperature system. A computerized model was connected to this circuit by pressure transducers, termistor probes, and a weight scale. VT, VE, f, PIP, I:E flows, P-V loops, and I:E temp. of PFC were continuously measured. Figure
Figure 1
Conclusion: This computerized system has proved its accuracy for the measurement of in vivo lung mechanics during TLV.
Grants FIS 95/1332, 95/1348 and UPV 025.350-TA115/95.
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Gómez, M., Casla, J., Vergara, J. et al. A PROTOTYPE COMPUTERIZED SYSTEM FOR MEASUREMENT OF LUNG MECHANICS DURING TOTAL LIQUID VENTILATION. 91. Pediatr Res 40, 530 (1996). https://doi.org/10.1203/00006450-199609000-00114
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DOI: https://doi.org/10.1203/00006450-199609000-00114
