Abstract
Analysis of cord blood lipids has been proposed for the early detection of familial hypercholesterolaemia and the assessment of the nutritional status of newborns. Lipid metabolism at birth, however is affected by several variables wich must be taken the relation between gestational age and birth weight and plasma lipids at birth making a factor analysis of the pormalized values (i.e. mean = 0. DS = 1) for total cholesterol (TC). triglycerides (TG). HDL cholesterol (HDL), birth weight and gestational age of 70 newborn. The range of birth weight was 2160-4730 g; the range of gestational age was 32-42 weeks. This analysis led to the extraction of three factors that explained 84, 7 % of the observed variance. The results are shown in a sequence of decreasing “eigenvalue”; only the coefficients above 0.20 are shown. The first factor links, as expected, gestational age and birth weight. The second is positively related to HDL and TC. The third factor, that summarizes an important degree of variation, shows that birth weight is negatively correlated with TC and positively with HDL.
These data indicate that cord blood lipids are related to birth weight. This variable must therefore be considered when screening for familial hypercholesterolaemia and assessing the nutritional status of newborns.
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Oriisi, M., Giovanhini, M., Bellu, R. et al. 59 FACTOR ANALYSIS OF CORD BLOOD LIPIDS. Pediatr Res 24, 270 (1988). https://doi.org/10.1203/00006450-198808000-00085
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DOI: https://doi.org/10.1203/00006450-198808000-00085
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