Abstract
The sera of twe nty five patients with JRA and the skin of ten of them were studied. Six patients had typical JRA rash. Their ages ranged from 5 to 15 years. Twelve patients with JRA demonstrated elevated levels of immune complexes (IC). The IC decreased during treatment and control of the disease. Five patients showed the presences of rheumatoid factor and antinuclear antibodies. There was good correlation between these abnormalities and treatment. The sera complement levels were normal in twenty patients. Punch biopsies were obtained from the site of rash or normal skin (control). Immunofluorescence staining revealed deposition of immunoglobulins or complement in 8 patients, six of whom had the rash and had systemic onset of disease. The fluorescence was positive for IgM (8), C3 (4) and IgG (1)mainly at the dermal-epidermal junction and vessels. Controls were negative. These data suggest, 1) positivity of IC in some aptients with JRA.2) Good correlation between IC and disease activity and, 3)The rash probably is immunological mediated.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Arroyave, C., Mejia, S. 979 IMMUNOLOGICAL ABNORMALITIES IN JUVENILE RHEUMATOID ARTHRITIS (JRA). Pediatr Res 15 (Suppl 4), 605 (1981). https://doi.org/10.1203/00006450-198104001-01004
Issue Date:
DOI: https://doi.org/10.1203/00006450-198104001-01004