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Water-soluble Naphthalene diimide (NDI) binds to the DNA duplex via threading intercalation mode. This has provided unique DNA analytical techniques, functional DNA polymers, and supramolecular polymers. Especially the ferrocene-containing NDIs, having electrochemically active sites, has been applied to an electrochemical gene detection system and also utilized in the precision analysis of genes and single nucleotide polymorphisms. Recently, NDI derivatives have been recognizing as potential candidate for anticancer therapeutics and for designing a unique cancer-detection system.
The mechanism of intense autopolymerization reaction of 2-bromo-3-methoxythiophenes spewing brownish gas was clarified from UV-Vis, ESR, GC/MS, elemental analysis, NMR, and FT-IR spectroscopy. The reaction contained the formation of the hydrogen bromide gas during the autopolymerization. The gas induced the cleavage of the methoxy group on the thiophene ring to form the methyl bromide gas as the side reaction. This work provides an important guide for the application of the autopolymerization of thiophene derivatives to design new polymer materials.
High-molecular-weight (HMW) benzoxazines were synthesized by Mannich condensation with various combinations of bisphenols and diamines, and the mechanical and thermal properties of the polybenzoxazines derived from the HMW benzoxazines were measured by tensile tests and thermogravimetric analysis to investigate the structure-property relationship. Among the polybenzoxazines presented in this work, the PODP-oda film derived from 4,4′-oxydiphenol and 4,4′-oxydianiline showed remarkably good mechanical properties (E = 3.7 GPa, sb = 125 MPa, and eb = 4.5%) and thermal stability (Td5 = 332 °C).
The microporosity of poly(1-trimethylsilyl-1-propyne) (PTMSP) and poly(4-methyl-2-pentyne) (PMP) is investigated by two independent methods—convenient low-temperature Ar sorption and less commonly used small-angle X-ray scattering (SAXS). The Brunauer–Emmett–Teller-specific surface values obtained for PTMSP and PMP from Ar sorption isotherms correlate with the specific surface values obtained from the SAXS method. The correlation of the specific surface values obtained from fundamentally different methods makes it possible to evaluate the small-angle scattering method as adequate for assessing the microporosity of polymeric materials.
This study comprehensively reveal the critical parameters of poly(ethylene oxide) (PEO) in the MD simulation that causes the numerical effect on polymer simulation and the variation of thermodynamics property. The threshold value of total molecular weight of 11,240 g/mol must be satisfied, which leads the polymer that exhibits its steady state bulk properties. For the oligomer system (Mw < 2248 g/mol per chain (50 monomers)), the total chain number must be more than 10 at least. The cooling rate must be lower than 5 × 1013 K/min for the structural equilibrium.
A gyroid nanostructured soft polymer film was developed by the co-organization of two types of amphiphile zwitterion monomers and a suitable acid into a bicontinuous cubic liquid-crystalline phase and subsequent in situ polymerization. The obtained polymer film showed a high ionic conductivity of 1.27 × 10–2 S cm–1 at a relative humidity of 90%.
Functional micellar nanocarriers for codelivery of doxorubicin (DOX) and caffeic acid phenethyl ester (CAPE) were successfully developed via coassembly of PEO113-b-PCL35-b-PEO113 and PAA13-b-PCL35-b-PAA13. CAPE was entrapped into the PCL core via hydrophobic interactions, while DOX was loaded in the middle layer through complexation between the amino and carboxylic groups of DOX and PAA. The dual drug-loaded micelles exhibited superior colloidal stability and sustained drug release profiles. The dual drug -loaded system suppressed the proliferation of mouse T-lymphoma L5178Y MDR1 cells more effectively than the single drug-loaded micelles, suggesting a synergistic effect.
We examined drug release behavior and anticancer efficacy of cyclodextrin-based nanoparticles (CDNPs) containing alpha-mangostin (MGS) in three different type of CDs (α-, β-, and γ-CD). βCDNP containing MGS demonstrated the best anticancer efficacy, while no efficacy was observed for the other CDNPs. Our findings suggested the anticancer efficacy might depend on the drug retention capability in which the interior and surface CDs in the CDNPs relate to the slow and rapid release modes, respectively. We assume the drug retention capability of slow release mode is important for performing the anticancer efficacy.
This study focuses on employing multilayer melt electrospinning of polymers coupled with a delamination step to obtain nonwoven webs of ribbon-shaped fibers. A coextrusion technique with layer multipliers was used to melt electrospin cylindrical microfibers that have up to 257 alternating layers within each fiber prior to delamination. The bicomponent layered cylindrical microfibers are delaminated using sonication or solvent rinsing to obtain flat nanoribbon fibers, that are 150 nanometers to 200 nanometers thick.
