Abstract
Synchronous or metachronous occurrences of both prostate cancer and male breast cancer are rarely reported, but provide insight into their hormonal and genetic biology. We sought to determine the incidence of prostate cancer in male breast cancer patients at our institution, and to examine estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu receptor (HR) status in these patients. A retrospective review was conducted of male breast cancer patients from 1990 to 2006. Histopathologic characteristics and hormone receptor expression was obtained. In 69 patients with male breast cancer, 12 (17%) also had a diagnosis of prostate cancer. Nine had ER-positive status and three were unreported. PR status was positive in 5, whereas 3 had PR-negative status. HR status was positive in 1, whereas 5 had HR-negative status. Male breast cancer patients in this cohort have an incidence of prostate cancer higher than would be predicted in the general population; this risk factor has implications for careful prostate cancer screening.
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References
Jemal A . Cancer statistics 2002. Can Cancer J Clin 2002; 52: 23–47.
Ravandi-Kashani F, Hayes TG . Male breast cancer: a review of the literature. Eur J Cancer 1998; 34: 1341–1347.
Ewertz M, Holmberg L, Karjalainen S, Tretli S, Adami HO . Incidence of male breast cancer in Scandinavia, 1943–1982. Int J Cancer 1989; 43: 27–31.
Devesa SS, Blot WJ, Stone BJ, Miller BA, Tarone RE, Fraumeni Jr JF . Recent cancer trends in the United States. J Natl Cancer Inst 1995; 87: 175–182.
Ojara EA . Carcinoma of the male breast in Mulago Hospital, Kampala. East Afr Med J 1978; 55: 489–491.
Bhagwandin S . Carcinoma of the male breast in Zambia. East Afr Med J 1972; 49: 176–179.
Fentiman IS, Fourquet A, Hortobagyi GN . Male breast cancer [published erratum appears in Lancet 2006; 367: 1818]. Lancet 2006; 367: 595–604.
Waterhouse J, Muir C, Correa P, Powell JR (eds) Cancer Incidence in Five Continents, Vol 3. IARC Science Publications, 1976.
Steinitz R, Katz L, Ben-Hur M . Male breast cancer in Israel: selected epidemiological aspects. J Med Sci 1981; 17: 816–821.
Satram-Hoang S, Ziogas A, Anton-Culver H . Risk of second primary cancer in men with breast cancer. Breast Cancer Res 2007; 9: R10; e-pub ahead of print January 25 2007.
Sherif M, Ibrahim AS, El-Aaser AA . Prostatic carcinoma in Egypt: epidemiology and etiology. Scand J Urol Nephrol Suppl 1980; 55: 25–26.
Sobin LH, Sherif M . Relation between male breast cancer and prostate cancer. J Cancer 1980; 42: 787.
Allen FJ, Van Velden DJ . Prostate carcinoma metastatic to male breast. Br J Urol 1991; 67: 424–435.
Gough DB, Donohue JH, Evans MM, Pernicone PJ, Wold LE, Naessens JM et al. A 50 year experience of male breast cancer: Is outcome changing? Surg Oncol 1993; 2: 325–333.
Sasco AJ, Lowenfels AB, Pasker-de Jong P . Review article: epidemiology of male breast cancer. A meta-analysis of published case–control studies and discussion of selected etiologic factors. Int J Cancer 1993; 53: 538–549.
Hultborn R, Hanson C, Köpf I, Verbiené I, Warnhammar E, Weimarck A . Prevalence of Klinefelter's syndrome in male breast cancer patients. Anticancer Res 1997; 17: 4293–4297.
Thomas DB, Jimenez LM, McTiernan A, Rosenblatt K, Stalsberg H, Stemhagen A et al. Breast cancer in men: risk factors with hormonal implications. Am J Epidemiol 1992; 135: 734–748.
Schlappack OK, Braun O, Maier U . Report of two cases of male breast cancer after prolonged estrogen treatment for prostatic carcinoma. Cancer Detect Prev 1986; 9: 319–322.
Calabresi E, De Giuli G, Becciolini A, Giannotti P, Lombardi G, Serio M . Plasma estrogens and androgens in male breast cancer. J Steroid Biochem 1976; 7: 605–609.
Ballerini P, Recchione C, Cavalleri A, Moneta R, Saccozzi R, Secreto G . Hormones in male breast cancer. Tumori 1990; 76: 26–28.
Mabuchi K, Bross DS, Kessler II . Risk factors in male breast cancer. J Natl Cancer Inst 1985, 929–930.
DÃez O, Cortés J, Domènech M, Pericay C, Brunet J, Alonso C et al. BRCA2 germ line mutations in Spanish male breast cancer patients. Ann Oncol 2000; 11: 81–84.
Thorlacius S, Tryggvadottir L, Olafsdottir GH, Jonasson JG, Ogmundsdottir HM, Tulinius H et al. Linkage of BRCA2 region in hereditary male breast cancer. Lancet 1995; 346: 544–545.
Friedman LS, Gayther SA, Kurosaki T, Gordon D, Noble B, Casey G et al. Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population. Am J Hum Genet 1997; 60: 313–319.
Sigurdsson S, Thorlacius S, Tomasson J, Tryggvadottir L, Benediktsdottir K, Eyfjörd JE et al. BRCA2 mutation in Icelandic prostate cancer patients. J Mol Med 1997; 75: 758–761.
Edwards SM, Kote-Jarai Z, Meitz J, Hamoudi R, Hope Q, Osin P, et al., Cancer Research UK/British Prostate Group UK Familial Prostate Cancer Study Collaborators; British Association of Urological Surgeons Section of Oncology. Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene. Am J Hum Genet 2003; 72: 1–12; e-pub ahead of print 9 December 2002.
Gayther SA . The frequency of germ-line mutations in the breast cancer predisposition genes BRCA1 and BRCA2 in familial prostate cancer. The Cancer Research Campaign/British Prostate Group United Kingdom Familial Prostate Cancer Study Collaborators. Cancer Res 2000; 60: 4513–4518.
Tryggvadóttir L, Vidarsdóttir L, Thorgeirsson T, Jonasson JG, Olafsdóttir EJ, Olafsdóttir GH et al. Prostate cancer progression and survival in BRCA2 mutation carriers. J Natl Cancer Inst 2007; 99: 929–935; e-pub ahead of print 12 June 2007.
Borgen PI, Wong GY, Vlamis V, Potter C, Hoffmann B, Kinne DW et al. Current management of male breast cancer: a review of 104 cases. Ann Surg 1992; 215: 451–459.
Jaiyesimi IA, Buzdar AU, Sahin AA, Ross MA . Carcinoma of the male breast. Ann Intern Med 1992; 117: 771–777.
Meijer-van Gelder ME, Look MP, Bolt-de Vries J, Peters HA, Klijn JG, Foekens JA . Clinical relevance of biologic factors in male breast cancer. Breast Cancer Res Treat 2001; 68: 249–260.
Terris MK, McCallum SW . Aromatase inhibitors for male infertility. J Urol 2002; 168: 1509.
Bardin A . Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer 2004; 11: 537–551.
Risbridger G, Wang H, Young P, Kurita T, Wang YZ, Lubahn D et al. Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium. Dev Biol 2001; 229: 432–442.
Leibowitz SB, Garber JE, Fox EA, Loda M, Kaufman DS, Kantoff PW et al. Male patients with diagnoses of both breast cancer and prostate cancer. Breast J 2003; 9: 208–212.
Thellenberg C, Malmer B, Tavelin B, Grönberg H . Second primary cancers in men with prostate cancer: an increased risk of male breast cancer. J Urol 2003; 169: 1345–1348.
Karlsson CT, Malmer B, Wiklund F, Gronberg H . Breast cancer as a second primary in patients with prostate cancer—estrogen treatment or association with family history of cancer? J Urol 2006; 176: 538–543.
American Cancer Society. Surveillance research 2006 based on cancer in North America, vol. 1, 1998–2002.
Pelzer AE, Tewari A, Bektic J, Berger AP, Frauscher F, Bartsch G et al. Detection rates and biologic significance of prostate cancer with PSA less than 4.0 ng/mL: observation and clinical implications from Tyrol screening project. Urology 2005; 66: 1029–1033.
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Lee, U., Jones, J. Incidence of prostate cancer in male breast cancer patients: a risk factor for prostate cancer screening. Prostate Cancer Prostatic Dis 12, 52–56 (2009). https://doi.org/10.1038/pcan.2008.26
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DOI: https://doi.org/10.1038/pcan.2008.26
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