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  • Oncogenomics
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The elusive multiple self-healing squamous epithelioma (MSSE) gene: further mapping, analysis of candidates, and loss of heterozygosity

Oncogene volume 25, pages 806–812 (2006)Cite this article

Abstract

The MSSE gene predisposes to multiple invasive but self-healing skin tumours (multiple self-healing epitheliomata). MSSE was previously mapped to chromosome 9q22–q31 and a shared haplotype in affected families suggested a founder mutation. We have refined the MSSE critical region (<1 cM, <1 Mb) between the zinc-finger gene ZNF169 and the Fanconi anaemia gene FANCC. By genetic mapping we have excluded ZNF169 and FANCC as well as PTCH (PATCHED) and TGFBR1 (transforming growth factor beta receptor type-1) genes. The CDC14B cell cycle phosphatase gene also lies in the region but screening of the complete coding region revealed no mutation in MSSE patients. Somatic cell hybrids created by haploid conversion of an MSSE patient's cells enabled screening of the MSSE chromosome 9 and showed no CDC14B deletion or mutation that abrogates CDC14B mRNA expression. Thus, CDC14B is unlikely to be the MSSE gene. We also report the first molecular analysis of MSSE tumours showing loss of heterozygosity of the MSSE region, with loss of the normal allele, providing the first evidence that MSSE is a tumour suppressor gene.

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Acknowledgements

We are grateful to all the MSSE families for their cooperation. We thank Professor Peter Farndon, Professor Sue Povey, Dr Roy Palmer, Dr Colin Arlett, Dr Arjida Woollons, Dr Anne-Marie Gerdes, Sean Humphray and dermatologists from across the UK for information and samples used in this study. This work was funded by the Medical Research Council and Tenovus, UK.

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Author notes

  1. S Bose

    Present address: Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

Authors and Affiliations

  1. Division of Reproductive and Child Health, Section of Medical and Molecular Genetics, University of Birmingham, Edgbaston, Birmingham, UK

    S Bose, L J Morgan & F M Richards

  2. Department of Pathology, University of Cambridge, Cambridge, UK

    D R Booth

  3. Department of Pathology, Ninewells Hospital and Medical School, Dundee, UK

    D R Goudie

  4. Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK

    M A Ferguson-Smith

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  1. S Bose
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  2. L J Morgan
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Correspondence to F M Richards.

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Bose, S., Morgan, L., Booth, D. et al. The elusive multiple self-healing squamous epithelioma (MSSE) gene: further mapping, analysis of candidates, and loss of heterozygosity. Oncogene 25, 806–812 (2006). https://doi.org/10.1038/sj.onc.1209092

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