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The retinoblastoma gene is involved in multiple aspects of stem cell biology

Oncogene volume 25, pages 5250–5256 (2006)Cite this article

Abstract

Genetic programs controlling self-renewal and multipotentiality of stem cells have overlapping pathways with cell cycle regulation. Components of cell cycle machinery can play a key role in regulating stem cell self-renewal, proliferation, differentiation and aging. Among the negative regulators of cell cycle progression, the RB family members play a prominent role in controlling several aspects of stem cell biology. Stem cells contribute to tissue homeostasis and must have molecular mechanisms that prevent senescence and hold ‘stemness’. RB can induce senescence-associated changes in gene expression and its activity is downregulated in stem cells to preserve self-renewal. Several reports evidenced that RB could play a role in lineage specification of several types of stem cells. RB has a role in myogenesis as well as in cardiogenesis. These effects are not only related to its role in suppressing E2F-responsive genes but also to its ability to modulate the activity of tissue-specific transcription factors. RB is also involved in adipogenesis through a strict control of lineage commitment and differentiation of adipocytes as well in determining the switch between brown and white adipocytes. Also, hematopoietic progenitor cells utilize the RB pathway to modulate cell commitment and differentiation. In this review, we will also discuss the role of the other two RB family members: Rb2/p130 and p107 showing that they have both specific and overlapping functions with RB gene.

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Acknowledgements

NIH grants and SBARRO Health Research Organization (AG). PRIN 2004 (UG). We thank Mrs MariaRosaria Cipollaro for administrative assistance and Dr Gianluca Abate for technical assistance.

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Authors and Affiliations

  1. Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, Temple University, Philadelphia, PA, USA

    U Galderisi & A Giordano

  2. Department of Experimental Medicine, Section of Biotechnology and Molecular Biology, Excellence Research Center for Cardiovascular Diseases, Second University of Naples, Naples, Italy

    U Galderisi & M Cipollaro

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  1. U Galderisi
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  2. M Cipollaro
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  3. A Giordano
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Correspondence to U Galderisi.

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Galderisi, U., Cipollaro, M. & Giordano, A. The retinoblastoma gene is involved in multiple aspects of stem cell biology. Oncogene 25, 5250–5256 (2006). https://doi.org/10.1038/sj.onc.1209736

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