Abstract
Protein kinases are critically involved in signaling pathways that regulate cell growth, differentiation, activation, and survival. Lck, a member of the Src family of protein tyrosine kinases, plays a key role in T-lymphocyte activation and differentiation. However, under certain conditions Lck is also involved in the induction of apoptosis. In this issue of Oncogene, Samraj et al. used the Lck-defective JCaM1.6 cell line to demonstrate the critical role of Lck in the apoptotic response of T-cell leukemia cells to several chemotherapeutic drugs. They further showed that Lck controls the mitochondrial death pathway by regulating proapoptotic Bak expression. This chemosensitizing effect of Lck is independent of T-cell receptor signaling and does not require the kinase activity of Lck. These findings demonstrate that Lck might be part of two independent signaling pathways leading to either cell proliferation or apoptosis, and reveal a hitherto unrecognized link between Lck, Bak, and chemosensitivity of human leukemic cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Antonsson B, Conti F, Ciavatta A, Montessuit S, Lewis S, Martinou I et al. (1997). Science 277: 370–372.
Belka C, Gruber C, Jendrossek V, Wesselborg S, Budach W . (2003). Oncogene 22: 176–185.
Belka C, Marini P, Lepple-Wienhues A, Budach W, Jekle A, Los M et al. (1999). Oncogene 18: 4983–4992.
Cartron PF, Juin P, Oliver L, Martin S, Meflah K, Vallette FM . (2003). Mol Cell Biol 23: 4701–4712.
Cheng J, Haas M . (1990). Mol Cell Biol 10: 5502–5509.
Ferri KF, Kroemer G . (2001). Nat Cell Biol 3: E255–E263.
Green DR, Reed JC . (1998). Science 281: 1309–1312.
Griffiths GJ, Dubrez L, Morgan CP, Jones NA, Whitehouse J, Corfe BM et al. (1999). J Cell Biol 144: 903–914.
Gruber C, Henkel M, Budach W, Belka C, Jendrossek V . (2004). Biochem Pharmacol 67: 1859–1872.
Hur YG, Yun Y, Won J . (2004). J Immunol 172: 79–87.
Klee M, Pimentel-Muinos FX . (2005). J Cell Biol 168: 723–734.
Manna SK, Aggarwal BB . (2000). J Immunol 164: 5156–5166.
Manna SK, Sah NK, Aggarwal BB . (2000). J Biol Chem 275: 13297–13306.
Molina TJ, Kishihara K, Siderovski DP, van Ewijk W, Narendran A, Timms E et al. (1992). Nature 357: 161–164.
Rouer E, Brule F, Benarous R . (1999). Oncogene 18: 4262–4268.
Samraj AK, Stroh C, Fischer U, Schulze-Osthoff K . (2005). Oncogene 25: 186–197.
Schuler M, Green DR . (2005). Trends Genet 21: 182–187.
Straus DB, Weiss A . (1992). Cell 70: 585–593.
Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M et al. (2000). Genes Dev 14: 2060–2071.
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ et al. (2001). Science 292: 727–730.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Heyninck, K., Beyaert, R. A novel link between Lck, Bak expression and chemosensitivity. Oncogene 25, 1693–1695 (2006). https://doi.org/10.1038/sj.onc.1209157
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1209157