Review

Oncogene (2005) 24, 2776–2786. doi:10.1038/sj.onc.1208613

Cyclin E in normal and neoplastic cell cycles

Harry C Hwang1 and Bruce E Clurman1,2

  1. 1Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
  2. 2Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA

Correspondence: BE Clurman, Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, D2-100, Seattle, WA 98109-1024, USA. E-mail: bclurman@fhcrc.org

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Abstract

Cyclin E-Cdk2 has long been considered an essential and master regulator of progression through G1 phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells.

Keywords:

cyclin E, Cdk, cell cycle, tumorigenesis