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Molecular interdiction of Src-family kinase signaling in hematopoietic cells

Oncogene volume 23, pages 8024–8032 (2004)Cite this article

Abstract

The ability of Src-family kinases (SFKs) to mediate signaling from cell surface receptors in hematopoietic cells is a function of their catalytic activity, location and binding partners. Kinase activity is regulated in the cell by kinases and phosphatases that alter the state of phosphorylation of key tyrosine residues and by protein binding partners that stabilize the kinase in active or inactive conformations or localize the enzyme to specific subcellular or submembrane domains. Kinase activity and function can be modulated experimentally through the use of small molecule inhibitors designed to directly target catalytic or binding domains or regulate the location of the protein by altering its state of acylation.

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Acknowledgements

Work in the author's laboratories is supported by grants NIH CA37372 (RLG) and NIH GM48099 (MLH). M Handley is supported by NIH Training Grant T32CA09634 awarded to the Purdue Cancer Center.

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    Robert L Geahlen, Misty D Handley & Marietta L Harrison

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Geahlen, R., Handley, M. & Harrison, M. Molecular interdiction of Src-family kinase signaling in hematopoietic cells. Oncogene 23, 8024–8032 (2004). https://doi.org/10.1038/sj.onc.1208078

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