Abstract
The 8;21 translocation produces a fusion between the ETO gene and that encoding the myeloid transcription factor AML1. The AML1–ETO fusion substitutes the majority of the ETO protein for the coregulator recruitment domains of AML1. Biochemical analyses of ETO have led to the identification of numerous interacting proteins including many corepressors. Importantly, the proteins interacting with ETO are different from those of wild-type AML1, suggesting that altered coregulator recruitment underlies the oncogenic properties of AML1–ETO. The list of corepressors capable of binding ETO includes histone deacetylases (HDACs) and components of distinct HDAC core complexes. These investigations have provided mechanistic insight into corepressor recruitment by ETO and clues to the leukemogenic activity of AML1–ETO.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S and Hiebert SW . (2001). Mol. Cell. Biol., 21, 6470–6483.
Ansieau S and Leutz A . (2002). J. Biol. Chem., 277, 4906–4910.
Brooks CL and Gu W . (2003). Curr. Opin. Cell Biol., 15, 164–171.
Davis JN, McGhee L and Meyers S . (2003). Gene, 303, 1–10.
Davis JN, Williams BJ, Herron JT, Galiano FJ and Meyers S . (1999). Oncogene, 18, 1375–1383.
Downing JR . (1999). Br. J. Haematol., 106, 296–308.
Erickson PF, Robinson M, Owens G and Drabkin HA . (1994). Cancer Res., 54, 1782–1786.
Espinas ML, Canudas S, Fanti L, Pimpinelli S, Casanova J and Azorin F . (2000). EMBO Rep., 1, 253–259.
Feinstein PG, Kornfeld K, Hogness DS and Mann RS . (1995). Genetics, 140, 573–586.
Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase T, Yokoyama Y and Ohki M . (1998). Blood, 91, 4028–4037.
Gelmetti V, Zhang J, Fanelli M, Minucci S, Pelicci PG and Lazar MA . (1998). Mol. Cell. Biol., 18, 7185–7191.
Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O and Srivastava D . (2002). Nat. Genet., 31, 25–32.
Gross CT and McGinnis W . (1996). EMBO J., 15, 1961–1970.
Guenther MG, Barak O and Lazar MA . (2001). Mol. Cell. Biol., 21, 6091–6101.
Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA and Shiekhattar R . (2000). Genes Dev., 14, 1048–1057.
Hildebrand D, Tiefenbach J, Heinzel T, Grez M and Maurer AB . (2001). J. Biol. Chem., 276, 9889–9895.
Hug BA, Lee SY, Kinsler EL, Zhang J and Lazar MA . (2002). Cancer Res., 62, 2906–2912.
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y and Howard BH . (2001). J. Biol. Chem., 276, 6817–6824.
Hung HL, Kim AY, Hong W, Rakowski C and Blobel GA . (2001). J. Biol. Chem., 276, 10715–10721.
Hung HL, Lau J, Kim AY, Weiss MJ and Blobel GA . (1999). Mol. Cell. Biol., 19, 3496–3505.
Iizuka M and Smith MM . (2003). Curr. Opin. Genet. Dev., 13, 154–160.
Ishizuka T and Lazar M . (2003). Mol. Cell. Biol., 23, 5122–5131.
Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y and Ohki M . (1998). Mol. Cell. Biol., 18, 846–858.
Kozu T, Komori A, Sueoka E, Fujiki H, Kaneko Y, Matsui T, Uehara T, Seino Y and Ishii M . (1997). Leukemia, 11, 297–298.
Li H, Leo C, Schroen DJ and Chen JD . (1997). Mol. Endocrinol., 11, 2025–2037.
Li J, Lin Q, Wang W, Wade P and Wong J . (2002). Genes Dev., 16, 687–692.
Li J, Wang J, Nawaz Z, Liu JM, Qin J and Wong J . (2000). EMBO J., 19, 4342–4350.
Lutterbach B, Sun D, Schuetz J and Hiebert SW . (1998a). Mol. Cell. Biol., 18, 3604–3611.
Lutterbach B, Westendorf JJ, Linggi B, Patten A, Moniwa M, Davie JR, Huynh KD, Bardwell VJ, Lavinsky RM, Rosenfeld MG, Glass C, Seto E and Hiebert SW . (1998b). Mol. Cell. Biol., 18, 7176–7184.
Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW and Licht JD . (2000). Mol. Cell. Biol., 20, 2075–2086.
Minucci S, Maccarana M, Cioce M, De Luca P, Gelmetti V, Segalla S, Di Croce L, Giavara S, Matteucci C, Gobbi A, Bianchini A, Colombo E, Schiavoni I, Badaracco G, Hu X, Lazar MA, Landsberger N, Nervi C and Pelicci PG . (2000). Mol. Cell, 5, 811–820.
Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N and Ohki M . (1993). EMBO J., 12, 2715–2721.
Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N and Ohki M . (2000). Gene, 241, 287–295.
Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL and Evans RM . (1997). Cell, 89, 373–380.
Odaka Y, Mally A, Elliott LT and Meyers S . (2000). Oncogene, 19, 3584–3597.
Parthun MR, Widom J and Gottschling DE . (1996). Cell, 87, 85–94.
Soderstrom M, Vo A, Heinzel T, Lavinsky RM, Yang WM, Seto E, Peterson DA, Rosenfeld MG and Glass CK . (1997). Mol. Endocrinol., 11, 682–692.
Wang J, Hoshino T, Redner RL, Kajigaya S and Liu JM . (1998). Proc. Natl. Acad. Sci. USA, 95, 10860–10865.
Wang L, Ding L, Jones CA and Jones RS . (2002). Gene, 285, 119–125.
Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG and Seto E . (2000). Proc. Natl. Acad. Sci. USA, 97, 7202–7207.
Wolford JK and Prochazka M . (1998). Gene, 212, 103–109.
Xue Y, Wong J, Moreno GT, Young MK, Cote J and Wang W . (1998). Mol. Cell, 2, 851–861.
Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J and Wong J . (2003). EMBO J., 22, 1336–1346.
You A, Tong JK, Grozinger CM and Schreiber SL . (2001). Proc. Natl. Acad. Sci. USA, 98, 1454–1458.
Yu J, Li Y, Ishizuka T, Guenther M and Lazar M . (2003). EMBO J., 22, 3403–3410.
Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG and Lazar MA . (2001). Mol. Cell. Biol., 21, 156–163.
Zhang J, Kalkum M, Chait BT and Roeder RG . (2002). Mol. Cell, 9, 611–623.
Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P and Reinberg D . (1997). Cell, 89, 357–364.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A and Reinberg D . (1999). Genes Dev., 13, 1924–1935.
Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M and Reinberg D . (1998). Mol. Cell, 1, 1021–1031.
Acknowledgements
Work in the authors' lab was supported by NIH HL004339 (BAH) and by NIH DK43806 and DK45586 (MAL).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Hug, B., Lazar, M. ETO interacting proteins. Oncogene 23, 4270–4274 (2004). https://doi.org/10.1038/sj.onc.1207674
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1207674
Keywords
This article is cited by
-
Zinc finger myeloid Nervy DEAF-1 type (ZMYND) domain containing proteins exert molecular interactions to implicate in carcinogenesis
Discover Oncology (2022)
-
RUNX1T1, a potential prognostic marker in breast cancer, is co-ordinately expressed with ERα, and regulated by estrogen receptor signalling in breast cancer cells
Molecular Biology Reports (2021)
-
Histone acetylation and reactive oxygen species are involved in the preprophase arrest induced by sodium butyrate in maize roots
Protoplasma (2017)
-
Co-repressor CBFA2T2 regulates pluripotency and germline development
Nature (2016)
-
RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1
Oncogenesis (2015)