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Coordinate regulation of cell growth and differentiation by TGF-β superfamily and Runx proteins

Oncogene volume 23, pages 4232–4237 (2004)Cite this article

Abstract

Runx proteins regulate various biological processes, including growth and differentiation of hematopoietic cells, lymphocytes, osteoblasts, and gastric epithelial cells. Some of the biological activities of Runx proteins are reminiscent of those of transforming growth factor (TGF)-β superfamily cytokines. Consistent with this notion, receptor-regulated Smads (R-Smads), signal mediators of the TGF-β superfamily cytokines, and Runx proteins have been shown to physically interact with each other. R-Smads activated by TGF-β and Runx proteins cooperatively induce synthesis of IgA in B lymphocytes, and those activated by bone morphogenetic proteins and Runx2 induce osteoblastic differentiation. Moreover, the R-Smad–Runx signaling pathways are regulated by an E3 ubiquitin ligase Smurf1, as well as a signal transducer of interferons, STAT1. Since Runxl and Runx3 are involved in the development of some cancers including acute leukemia and gastric cancer, it will be of interest to examine in detail whether TGF-β-specific R-Smads and Runx proteins coordinately regulate growth and differentiation of hematopoietic cells and gastric epithelial cells.

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Acknowledgements

We thank Drs Tadatsugu Taniguchi and Hiroshi Takayanagi for sharing unpublished observations. We also thank Keiji Miyazawa, Hiromi Fukuda, and Masao Saitoh for the valuable discussion. This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Technology, Sports and Culture of Japan.

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  1. Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Tokyo, 113-0033, Bunkyo-ku, Japan

    Kohei Miyazono

  2. Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), 1-37-1 Kami-ikebukuro, Tokyo, 170-8455, Toshima-ku, Japan

    Kohei Miyazono, Shingo Maeda & Takeshi Imamura

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  1. Kohei Miyazono
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Correspondence to Kohei Miyazono.

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Miyazono, K., Maeda, S. & Imamura, T. Coordinate regulation of cell growth and differentiation by TGF-β superfamily and Runx proteins. Oncogene 23, 4232–4237 (2004). https://doi.org/10.1038/sj.onc.1207131

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